INT168714

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Buprenorphine 1 99.88 Very High Very High Very High
Morphine 4 99.24 Very High Very High Very High
Opioid 4 99.04 Very High Very High Very High
tolerance 2 98.40 Very High Very High Very High
Analgesic 4 98.20 Very High Very High Very High
opioid receptor 5 91.60 High High
methadone 1 90.96 High High
Oxycodone 1 89.76 High High
Kappa opioid receptor 2 85.04 High High
agonist 2 76.40 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute analgesic tolerance to morphine and related opioids (morphine-6-glucuronide and buprenorphine) was blocked by JNK inhibition, but not by G protein receptor kinase 3 knockout.
Negative_regulation (blocked) of JNK Neg (inhibition) Binding (inhibition) of associated with targeted disruption, analgesic, tolerance, opioid, buprenorphine and morphine
1) Confidence 0.36 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20534436 Disease Relevance 0.18 Pain Relevance 1.62

General Comments

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