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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mapk8, Mapk8, Oprk1) mitochondrion (Mapk8, Mapk8) cytoplasm (Mapk8, Mapk8)
cytosol (Mapk8, Mapk8) nucleus (Mapk8, Mapk8) kinase activity (Mapk8, Mapk8)
Mapk8 (Mus musculus)
Mapk8 (Mus musculus)
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 2 100.00 Very High Very High Very High
agonist 2 99.16 Very High Very High Very High
Opioid 4 97.24 Very High Very High Very High
Analgesic 4 96.96 Very High Very High Very High
Enkephalin 2 95.84 Very High Very High Very High
Morphine 4 91.28 High High
opioid receptor 5 91.16 High High
Spinal cord 1 90.32 High High
tolerance 2 81.52 Quite High
Oxycodone 1 80.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
JNK-mediated receptor inactivation of the kappa-opioid receptor was evident in both agonist-stimulated [(35)S]GTPgammaS binding and opioid analgesic assays; however, gene knockout of JNK 1 selectively blocked kappa-receptor inactivation, whereas deletion of JNK 2 selectively blocked MOR inactivation.
JNK Positive_regulation (mediated) of JNK Negative_regulation (inactivation) of kappa-opioid receptor associated with targeted disruption, analgesic, agonist, kappa opioid receptor, opioid receptor and opioid
1) Confidence 0.19 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20534436 Disease Relevance 0.26 Pain Relevance 1.75

General Comments

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