INT168736

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 0.24
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
trigeminal ganglion 1
gingiva 1
stems 1
dental pulp 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Codeine 763 99.98 Very High Very High Very High
Morphine 112 99.54 Very High Very High Very High
Inflammation 6 50.00 Quite Low
Neuropeptide 6 50.00 Quite Low
Dopamine 133 5.00 Very Low Very Low Very Low
withdrawal 7 5.00 Very Low Very Low Very Low
opiate 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
pulpitis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulpitis 3 80.56 Quite High
INFLAMMATION 6 50.00 Quite Low
Sprains And Strains 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Cough 7 5.00 Very Low Very Low Very Low
Diarrhoea 7 5.00 Very Low Very Low Very Low
Drug Dependence 7 5.00 Very Low Very Low Very Low
Mental Disorders 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: RT-PCR revealed the presence of NPY-Y1R in the dental pulp, trigeminal ganglion and gingiva.
NPY-Y1R Binding (presence) of in trigeminal ganglion
1) Confidence 0.35 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.08 Pain Relevance 0
As a result, further analysis through truncation experiments was conducted to determine the crucial sequences involved in codeine-binding for two aptamers (FC5 and FC45) that exhibited the highest binding affinities of those analyzed.


FC5 Binding (binding) of associated with codeine
2) Confidence 0.15 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.55
M when characterized through the described Biacore assay; however, several of its member sequences, including FC5 and FC45, were determined to have higher affinities to codeine.
FC5 Binding (several) of associated with codeine
3) Confidence 0.13 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.69
RESULTS: RT-PCR revealed the presence of NPY-Y1R in the dental pulp, trigeminal ganglion and gingiva.
NPY-Y1R Binding (presence) of in gingiva
4) Confidence 0.12 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.08 Pain Relevance 0
RESULTS: RT-PCR revealed the presence of NPY-Y1R in the dental pulp, trigeminal ganglion and gingiva.
NPY-Y1R Binding (presence) of in dental pulp
5) Confidence 0.12 Published 2010 Journal Int Endod J Section Body Doc Link 20536577 Disease Relevance 0.08 Pain Relevance 0
Therefore, the proposed secondary structures of the FC5 and FC45 mini-aptamers may be evaluated by examining the binding properties of these aptamers modified with stabilized base stems.
FC5 Binding (binding) of in stems
6) Confidence 0.11 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.12
In addition, both FC5 and FC45 mini-aptamers lack the 3?
FC5 Binding (mini) of
7) Confidence 0.11 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.47
Two highest binding aptamer sequences, FC5 and FC45 with Kd values of 2.50 and 4.00 ?
FC5 Binding (binding) of
8) Confidence 0.11 Published 2006 Journal Nucleic Acids Research Section Abstract Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.37
M), whereas FC5 was determined to bind free codeine with an ?
FC5 Spec (determined) Binding (bind) of associated with codeine
9) Confidence 0.11 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.46
M to morphine, whereas the solution affinity for FC5 was determined to be ?
FC5 Binding (affinity) of associated with morphine
10) Confidence 0.11 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 1.23

General Comments

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