INT168758

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.44
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hist1h1t, Akt1) nucleoplasm (Akt1) cell differentiation (Hist1h1t)
transport (Akt1) aging (Akt1) DNA binding (Hist1h1t)
Hist1h1t (Rattus norvegicus)
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 395 100.00 Very High Very High Very High
antagonist 111 97.44 Very High Very High Very High
agonist 33 95.20 Very High Very High Very High
analgesia 62 95.08 Very High Very High Very High
Opioid 36 91.24 High High
Pain 43 88.80 High High
Analgesic 50 87.68 High High
antinociception 15 84.96 Quite High
Visceral pain 47 80.80 Quite High
withdrawal 6 67.20 Quite High
Disease Link Frequency Relevance Heat
Pain 33 88.80 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

96 88.28 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

47 80.80 Quite High
Nociception 21 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Colitis 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H2S caused MOR transactivation and internalization in SKNMCs by a mechanism that required AKT phosphorylation.
H2S Positive_regulation (required) of Phosphorylation (phosphorylation) of AKT
1) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link 20540729 Disease Relevance 0 Pain Relevance 0
Because H2S induces AKT phosphorylation [21] and AKT is also activated in response to MOR activation by DAMGO [22], we have investigated whether Na2S induces AKT phosphorylation in SKNMCs.
H2S Positive_regulation (induces) of Phosphorylation (phosphorylation) of AKT associated with opioid receptor
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.57
H2S caused MOR transactivation and internalization in SKNMCs by a mechanism that required AKT phosphorylation.
H2S Positive_regulation (required) of Phosphorylation (phosphorylation) of AKT associated with opioid receptor
3) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2908066 Disease Relevance 0.09 Pain Relevance 1.77
Results form mechanistic studies aimed at dissecting intracellular signals activated by H2S in SKNMCs have shown that H2S activates the PI3K/AKT pathway and induces AKT phosphorylation [21].
H2S Positive_regulation (induces) of Phosphorylation (phosphorylation) of AKT
4) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.45

General Comments

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