INT16879

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2009
Negated 3
Speculated 1
Reported most in Abstract
Documents 72
Total Number 73
Disease Relevance 21.65
Pain Relevance 28.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
neurons 5
CSF 3
CeA 3
locus coeruleus 3
brain 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 81 100.00 Very High Very High Very High
Opioid 51 100.00 Very High Very High Very High
narcan 48 100.00 Very High Very High Very High
Enkephalin 45 100.00 Very High Very High Very High
opiate 40 100.00 Very High Very High Very High
Neuropeptide 31 100.00 Very High Very High Very High
Endogenous opioid 28 100.00 Very High Very High Very High
Neurotransmitter 25 100.00 Very High Very High Very High
Cholecystokinin 24 100.00 Very High Very High Very High
substance P 20 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 212 100.00 Very High Very High Very High
Gastric Motility Disorder 8 100.00 Very High Very High Very High
Anxiety Disorder 67 99.88 Very High Very High Very High
Depression 25 99.88 Very High Very High Very High
Pain 68 99.80 Very High Very High Very High
Sleep Disorders 42 99.80 Very High Very High Very High
Injury 15 99.68 Very High Very High Very High
Congenital Anomalies 1 99.52 Very High Very High Very High
Ileus 6 99.26 Very High Very High Very High
Urological Neuroanatomy 10 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies provide evidence for a 5-HT/CRH interaction in the regulation of anxiety.
CRH Binding (interaction) of associated with anxiety disorder
1) Confidence 0.48 Published 1999 Journal Neuroreport Section Abstract Doc Link 10208588 Disease Relevance 0.17 Pain Relevance 0.65
Interaction of arginine vasopressin and corticotropin releasing factor demonstrated with an improved bioassay.
corticotropin releasing factor Binding (Interaction) of
2) Confidence 0.48 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 3873659 Disease Relevance 0.08 Pain Relevance 0.18
Interactions between corticotropin-releasing factor and endogenous opiates on the cardioaccelerator, hypothermic, and corticoid responses to restraint in the rat.
corticotropin-releasing factor Binding (Interactions) of associated with narcan and opiate
3) Confidence 0.48 Published 1993 Journal Peptides Section Title Doc Link 8483794 Disease Relevance 0.58 Pain Relevance 0.39
The data obtained suggest that CRF(4-6) can either directly interact with corticoliberin receptors or modulate activity of CRF-ergic neurons.
corticoliberin Binding (interact) of in neurons
4) Confidence 0.48 Published 2005 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 16353480 Disease Relevance 0.24 Pain Relevance 0.48
These results support previous reports of in vitro potentiation of CRF-41 by AVP and point out the complexity of CRF-neurohypophyseal hormone interaction in vivo.
CRF-neurohypophyseal hormone Binding (interaction) of
5) Confidence 0.48 Published 1984 Journal Life Sci. Section Abstract Doc Link 6332965 Disease Relevance 0 Pain Relevance 0.15
It can be suggested that the tripeptide either directly interacts with corticoliberin receptors or modulates the activity of CRFergic neurons.
corticoliberin Binding (interacts) of in neurons
6) Confidence 0.48 Published 2007 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 17180318 Disease Relevance 0.14 Pain Relevance 0.32
Although the precise mechanisms are not clear, and the involvement of noradrenergic systems cannot be precluded, data are consistent with the idea that dopamine, released in response to a stressful experience for example, interacts with CRH and neurotensin in the extended amygdala to affect emotional responsiveness.
CRH Binding (interacts) of in amygdala associated with dopamine and amygdala
7) Confidence 0.48 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.60
Further studies are needed to better understand the nature of the association between CSF CRF and pain symptoms in FM.
CSF CRF Binding (association) of in CSF associated with pain and fibrositis
8) Confidence 0.47 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16936702 Disease Relevance 1.63 Pain Relevance 0.95
In multivariate analyses adjusting for age, sex, and depressive symptoms, the association between CSF CRF and sensory pain symptoms (t=2.54, p=0.027) persisted.
CSF CRF Binding (association) of in CSF associated with pain and depression
9) Confidence 0.47 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16936702 Disease Relevance 1.98 Pain Relevance 1.16
This modifiability of the interaction between CRF and the LC may represent the operation of mechanisms mediating adaptive responding to stress.
CRF Binding (interaction) of associated with stress and locus ceruleus
10) Confidence 0.47 Published 1996 Journal Brain Res. Section Abstract Doc Link 8813346 Disease Relevance 0.80 Pain Relevance 0.41
The present study was undertaken to evaluate the role and possible interaction of the endogenous opioid peptide (EOP) and corticotropin-releasing factor (CRF) in the acute stress-induced suppression of gonadotropin secretion in ovariectomized estrogen-primed rats.
CRF Binding (interaction) of associated with stress and endogenous opioid
11) Confidence 0.47 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8866253 Disease Relevance 0.23 Pain Relevance 0.29
The present study was undertaken to evaluate the role and possible interaction of the endogenous opioid peptide (EOP) and corticotropin-releasing factor (CRF) in the acute stress-induced suppression of gonadotropin secretion in ovariectomized estrogen-primed rats.
corticotropin-releasing factor Binding (interaction) of associated with stress and endogenous opioid
12) Confidence 0.47 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8866253 Disease Relevance 0.23 Pain Relevance 0.29
RESULTS: Evidence is reviewed supporting the hypothesis that CRF and endogenous opioids interact to co-regulate the LC.
CRF Binding (interact) of
13) Confidence 0.46 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11797054 Disease Relevance 0.16 Pain Relevance 0
Finally, a history of stress or opiate use induces plasticity in CRF-LC or opiate-LC interactions, respectively.
CRF Binding (interactions) of
14) Confidence 0.46 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11797054 Disease Relevance 0.13 Pain Relevance 0
Thus, our working model is that CRF, in part via interactions with brainstem serotonergic systems, modulates context-dependent behavioral responses to perceived threats, including both anxiety-related risk assessment behaviors and fight-or-flight locomotor responses.
CRF Binding (interactions) of in brainstem associated with medulla and anxiety disorder
15) Confidence 0.45 Published 2006 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 16426606 Disease Relevance 0.39 Pain Relevance 0.45
Interaction of corticotropin-releasing factor and arginine vasopressin on adrenocorticotropin secretion in vivo.
corticotropin-releasing factor Binding (Interaction) of
16) Confidence 0.42 Published 1983 Journal Endocrinology Section Title Doc Link 6307672 Disease Relevance 0 Pain Relevance 0.09
There was no evidence that CRH selectively enhanced or interfered with novelty-induced behavioral changes; it influenced behavior to the same degree in both test conditions.
CRH Binding (interfered) of
17) Confidence 0.37 Published 1987 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3496617 Disease Relevance 0 Pain Relevance 0.13
This study examines the contribution of central corticotropin-releasing factor (CRF) to pain behavior.
CRF Binding (contribution) of associated with pain
18) Confidence 0.37 Published 2006 Journal Pain Section Abstract Doc Link 16495007 Disease Relevance 0.34 Pain Relevance 0.54
This study examines the contribution of central corticotropin-releasing factor (CRF) to pain behavior.
corticotropin-releasing factor Binding (contribution) of associated with pain
19) Confidence 0.37 Published 2006 Journal Pain Section Abstract Doc Link 16495007 Disease Relevance 0.34 Pain Relevance 0.54
We developed an improved in vivo bioassay for corticotropin releasing factor (CRF) by modifying the injection schedule in the standard chlorpromazine-morphine-pentobarbital assay procedure.
CRF Binding (bioassay) of associated with morphine
20) Confidence 0.37 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3873659 Disease Relevance 0.07 Pain Relevance 0.19

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