INT168801

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.70
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
nucleus 2
macrophages 1
finger 1
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7 99.98 Very High Very High Very High
Inflammation 35 97.88 Very High Very High Very High
Central nervous system 2 95.80 Very High Very High Very High
Hippocampus 10 91.92 High High
Pyramidal cell 1 86.96 High High
medulla 1 85.80 High High
amygdala 2 83.16 Quite High
GABAergic 2 59.60 Quite High
metalloproteinase 6 46.72 Quite Low
fibrosis 29 44.52 Quite Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 2 100.00 Very High Very High Very High
INFLAMMATION 32 97.88 Very High Very High Very High
Radiation Sickness 2 97.08 Very High Very High Very High
Myopia 26 85.92 High High
Shock 23 77.76 Quite High
Sprains And Strains 3 66.00 Quite High
Disease 7 58.24 Quite High
Peripheral Neuropathy 3 45.60 Quite Low
Fibrosis 11 44.52 Quite Low
Pain 1 41.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The zinc-finger protein Egr-1 is located in the nucleus [32-34] and has numerous target genes [35], among which are PDGF-A [36] and PDGF-B [37], bFGF [38] and TGF-?
Localization (located) of Egr-1 in nucleus
1) Confidence 0.78 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.18 Pain Relevance 0.03
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Localization (peptidase) of Egr-1 in finger associated with osteogenic sarcomas
2) Confidence 0.73 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0
Our findings point out to Egr-1 and NF-kappaB cooperation as determinant for PGE2 synthesis by macrophages in inflammatory processes through the coordinated regulation of COX-2 and mPGES-1.
Localization (cooperation) of Egr-1 in macrophages associated with inflammation
3) Confidence 0.50 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.21 Pain Relevance 0.08
Cytokine group (12 transcripts mRNAs): CCL2, IL1B, IL6, CSF2, CSF3, IFNG, IRAK1, IRAK2, NLRP2, KAT2B, STAT1, and EGR1 (All abbreviations are current Entrez Gene official symbols and official full names are presented in Table S1).
Localization (group) of EGR1 associated with cytokine
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.20 Pain Relevance 0.11
In contrast to Egr1 and Egr3, Egr2 protein has been detected in both the nucleus and cytoplasm of forebrain neurons (De et al., 2003; Mack et al., 1992).
Localization (detected) of Egr1 in nucleus
5) Confidence 0.33 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.26

General Comments

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