INT168825

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

MIR200A (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 78.48 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 20 99.98 Very High Very High Very High
Cancer 2 94.64 High High
Pancreatitis 2 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels.
Gene_expression (overexpress) of miR-200a associated with pancreatic cancer
1) Confidence 0.58 Published 2010 Journal Cancer Res. Section Title Doc Link 20551052 Disease Relevance 0.56 Pain Relevance 0
However, most pancreatic cancers express miR-200a and miR-200b, but this expression does not affect SIP1 expression, as the SIP1 promoter is silenced by hypermethylation and in these cancers E-cadherin is generally expressed.
Gene_expression (express) of miR-200a associated with cancer and pancreatic cancer
2) Confidence 0.58 Published 2010 Journal Cancer Res. Section Abstract Doc Link 20551052 Disease Relevance 0.87 Pain Relevance 0.08

General Comments

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