INT16883

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Context Info
Confidence 0.39
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 3.93
Pain Relevance 6.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
petrosal ganglion 4
dentate gyrus 2
B cells 2
amygdala 2
hippocampus 2
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 52 100.00 Very High Very High Very High
withdrawal 9 99.50 Very High Very High Very High
amygdala 3 99.36 Very High Very High Very High
Morphine 4 99.28 Very High Very High Very High
Hippocampus 7 99.04 Very High Very High Very High
Rostral ventrolateral medulla 5 98.04 Very High Very High Very High
Stimulus evoked pain 12 97.28 Very High Very High Very High
opiate 6 96.90 Very High Very High Very High
Somatostatin 9 96.80 Very High Very High Very High
narcan 4 96.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4 99.70 Very High Very High Very High
Eating Disorder 4 99.44 Very High Very High Very High
Convulsion 4 97.88 Very High Very High Very High
Ganglion Cysts 10 97.80 Very High Very High Very High
Pain 69 97.28 Very High Very High Very High
Hypersensitivity 15 97.08 Very High Very High Very High
INFLAMMATION 87 94.72 High High
Epilepsy 1 91.96 High High
Thyroid Disease 2 89.94 High High
Nociception 45 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Food restriction and diabetes both markedly increased the levels of Prodyn mRNA in the central amygdala (163% and 93%, respectively).
Positive_regulation (increased) of Gene_expression (levels) of Prodyn mRNA in amygdala associated with diabetes mellitus, amygdala and eating disorder
1) Confidence 0.39 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191075 Disease Relevance 0.64 Pain Relevance 0.36
Sorting by flow cytometry of cycloheximide-treated cells followed by in situ hybridization analysis revealed that the expression of PEA mRNA was exclusively confined to a small fraction of B cells.
Positive_regulation (confined) of Gene_expression (expression) of mRNA in B cells
2) Confidence 0.19 Published 1991 Journal Endocrinology Section Abstract Doc Link 1855463 Disease Relevance 0 Pain Relevance 0.11
The expression of PEA mRNA was markedly enhanced after a short incubation (3 h) of cells with LPS or Salmonella typhimurium.
Positive_regulation (enhanced) of Gene_expression (expression) of mRNA
3) Confidence 0.06 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2584715 Disease Relevance 0 Pain Relevance 0.20
This effect could be directly mediated though the thyroid hormone nuclear receptor or could be secondary to changes in glutamatergic transmission in the dentate gyrus, as suggested by the profound alteration of the KA-induced expression of DYN mRNA in the dentate gyrus of hypo-and hyperthyroid rats.
Positive_regulation (induced) of Gene_expression (expression) of DYN mRNA in dentate gyrus associated with dynorphin
4) Confidence 0.06 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583317 Disease Relevance 0.06 Pain Relevance 0.63
Our results can be summarized as follows: (1) hypothyroidism induces an up-regulation of ENK mRNA in the granule cells of the dentate gyrus and layers V/VI of the cingulate cortex and of DYN mRNA in the granule cells of the dentate gyrus; (2) the up-regulation of ENK mRNA expression in the granule cells induced by KA is not modified by altered thyroid status; (3) in contrast, the KA injection fails to up-regulate DYN precursor mRNA expression in the granule cells of the rostral dentate gyrus of the hypothyroid rats; (4) injection of KA in hyperthyroid rats increases the expression of DYN mRNA in the granule dentate gyrus more than in euthyroid rats.
Positive_regulation (increases) of Gene_expression (expression) of DYN mRNA in granule cells associated with dynorphin, thyroid disease and enkephalin
5) Confidence 0.04 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583317 Disease Relevance 0.09 Pain Relevance 0.92
DbetaH mRNA expression was not induced nor was PPE mRNA expression increased in the petrosal ganglion in treated animals.
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of DbetaH mRNA in petrosal ganglion associated with ganglion cysts
6) Confidence 0.04 Published 2001 Journal J. Appl. Physiol. Section Abstract Doc Link 11641357 Disease Relevance 0.50 Pain Relevance 0.66
Northern blot analysis showed a significant increase in the Gsalpha mRNA expression level in the bilateral hippocampus at 24h after the last generalized seizure.
Positive_regulation (increase) of Gene_expression (expression) of mRNA in hippocampus associated with convulsion and hippocampus
7) Confidence 0.04 Published 2000 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 10803814 Disease Relevance 0.36 Pain Relevance 0.38
DbetaH mRNA expression was not induced nor was PPE mRNA expression increased in the petrosal ganglion in treated animals.
Neg (not) Positive_regulation (induced) of Gene_expression (expression) of DbetaH mRNA in petrosal ganglion associated with ganglion cysts
8) Confidence 0.03 Published 2001 Journal J. Appl. Physiol. Section Abstract Doc Link 11641357 Disease Relevance 0.50 Pain Relevance 0.66
The link between the ERK activation and proDYN expression was investigated in a study by Woolf et al. in which they used a MEK Inhibitor U0126, which is a chemically synthesized organic compound that inhibits the kinase activity of MAP kinase, to block ERK activation and subsequently found a decrease in the CFA-induced proDYN mRNA expression[17].
Positive_regulation (induced) of Gene_expression (expression) of proDYN mRNA
9) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978219 Disease Relevance 0.74 Pain Relevance 0.39
Our results were compatible with the findings of other studies, in that an increased pERK level was associated with an increase in the expression of the proDYN mRNA, which may contribute to the development of reinflammation-induced pain hypersensitivity (decreased PWL) after neonatal peripheral inflammation.


Positive_regulation (increase) of Gene_expression (expression) of proDYN mRNA associated with inflammation, hypersensitivity and stimulus evoked pain
10) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978219 Disease Relevance 0.97 Pain Relevance 0.45
A significant increase in proDYN mRNA expression was detected in the neonatal CFA group (n = 10) compared with its expression levels in the neonatal saline group (n = 10), the neonatal non-treated group (n = 10) and the naive group (n = 10).
Positive_regulation (increase) of Gene_expression (expression) of proDYN mRNA
11) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978219 Disease Relevance 0 Pain Relevance 0.09
These cells were small (107 microm(2)) and expressed high levels of preprosomatostatin mRNA.
Positive_regulation (levels) of Gene_expression (essed hig) of preprosomatostatin mRNA
12) Confidence 0.02 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12508323 Disease Relevance 0.07 Pain Relevance 0.64
After the chronic treatments, spontaneous (48 h) or naloxone (2 mg/kg)-precipitated opiate withdrawal (2 h) resulted in up-regulation of PKC-alphabeta above control levels (30-38%), and in the case of morphine withdrawal in a concomitant marked increase in the expression of PKC-alpha mRNA levels (2.3-fold).
Positive_regulation (increase) of Gene_expression (expression) of mRNA associated with narcan, opiate, withdrawal and morphine
13) Confidence 0.01 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9109366 Disease Relevance 0 Pain Relevance 1.40

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