INT168841

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UBR1) ligase activity (UBR1) cytoplasm (UBR1)
UBR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 1 95.36 Very High Very High Very High
Glutamate 1 90.24 High High
rheumatoid arthritis 2 9.96 Low Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 96.66 Very High Very High Very High
Cancer 4 96.48 Very High Very High Very High
Disease 15 81.32 Quite High
Rheumatoid Arthritis 2 9.96 Low Low
Manic Depressive Disorder 1 8.48 Low Low
Diabetes Mellitus 4 7.28 Low Low
Disorder Of Lipid Metabolism 8 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Cardiovascular Disease 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the metabolic footprint of this association is that of an amino acid interconversion, which is supported by the functional role of PARK2 as a ubiquitin ligase in the protein degradation pathway.
Protein_catabolism (degradation) of ligase
1) Confidence 0.03 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581785 Disease Relevance 0.08 Pain Relevance 0.05
We characterize a new Myc-interacting factor, TRPC4AP (transient receptor potential cation channel, subfamily C, member 4-associated protein)/TRUSS (tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein), which is the receptor for a DDB1 (damage-specific DNA-binding protein 1)-CUL4 (Cullin 4) E3 ligase complex for selective Myc degradation through the proteasome.
Protein_catabolism (degradation) of ligase associated with necrosis, cancer and member 8
2) Confidence 0.00 Published 2010 Journal Genes Dev. Section Abstract Doc Link 20551172 Disease Relevance 0.34 Pain Relevance 0.10

General Comments

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