INT168863

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.88
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Wdtc1) histone binding (Wdtc1) nucleus (Wdtc1)
Anatomy Link Frequency
adipose tissue 1
Wdtc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 100.00 Very High Very High Very High
Morphine 9 99.80 Very High Very High Very High
antinociception 3 99.44 Very High Very High Very High
tolerance 6 98.64 Very High Very High Very High
Antinociceptive 2 81.00 Quite High
Potency 3 80.36 Quite High
Intracerebroventricular 2 79.20 Quite High
Endocannabinoid 35 75.00 Quite High
dexamethasone 1 70.24 Quite High
tail-flick 1 55.56 Quite High
Disease Link Frequency Relevance Heat
Obesity 196 100.00 Very High Very High Very High
Diabetes Mellitus 39 97.48 Very High Very High Very High
Disorder Of Lipid Metabolism 14 92.76 High High
Targeted Disruption 4 61.32 Quite High
Insulin Resistance 17 59.24 Quite High
Hypothermia 1 54.72 Quite High
Hyperplasia 3 54.12 Quite High
Hypertrophy 2 27.08 Quite Low
Chronic Disease 1 14.52 Low Low
Nicotine Addiction 1 6.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
cells undergo an adipose conversion characterized by the transcriptional
Regulation (undergo) of adipose
1) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.29 Pain Relevance 0.04
Role of CD38, a cyclic ADP-ribosylcyclase, in morphine antinociception and tolerance.
Regulation (Role) of ADP-ribosylcyclase associated with pain, antinociception, tolerance and morphine
2) Confidence 0.01 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 20551293 Disease Relevance 0.12 Pain Relevance 1.35
The observed alterations emphasize, for the first time in humans, the potential different role and regulation of adipose tissue anandamide (and its congeners) and 2-AG in obesity and type 2 diabetes.



Regulation (regulation) of adipose in adipose tissue associated with diabetes mellitus and obesity
3) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2868848 Disease Relevance 1.47 Pain Relevance 0.06

General Comments

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