INT168866

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR1, Cd38) hydrolase activity, acting on glycosyl bonds (Cd38) nucleus (Cd38)
transmembrane transport (RYR1) cytoplasm (RYR1)
RYR1 (Homo sapiens)
Cd38 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 9 98.88 Very High Very High Very High
tolerance 6 98.52 Very High Very High Very High
tail-flick 1 88.56 High High
Antinociceptive 2 84.24 Quite High
antinociception 3 75.00 Quite High
Intracerebroventricular 2 70.28 Quite High
Potency 1 63.64 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypothermia 1 89.44 High High
Targeted Disruption 1 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that cADRP-ryanodine receptor Ca(2+) signaling associated with CD38 plays an important role in morphine tolerance.
cADRP-ryanodine receptor Binding (associated) of CD38 associated with tolerance and morphine
1) Confidence 0.02 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20551293 Disease Relevance 0.17 Pain Relevance 1.28

General Comments

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