INT168888

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod4) nucleus (Neurod4) DNA binding (Neurod4)
Anatomy Link Frequency
synaptic vesicle 1
Neurod4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 98.70 Very High Very High Very High
opioid receptor 3 94.96 High High
Morphine 5 94.20 High High
trigeminal ganglion 66 92.64 High High
Neurotransmitter 3 65.96 Quite High
Neuropeptide 4 25.00 Low Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 18 94.52 High High
Ganglion Cysts 70 92.64 High High
Neurodegenerative Disease 6 62.60 Quite High
Repression 4 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These differentially regulated transcripts include the transcription factors Tcfap2b, Gata3 and NeuroD4, the calcium binding protein calbindin2 (calretinin), and the small GTP-binding protein Rab3b, implicated in synaptic vesicle release [34].
Transcription (transcription) of NeuroD4 in synaptic vesicle
1) Confidence 0.66 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.62 Pain Relevance 0.23
The differential effects of agonists on NeuroD activity were further confirmed by measuring the mRNA levels of four NeuroD downstream targets: doublecortin, Notch1, neurogenic differentiation 4, and Roundabout 1.
Transcription (levels) of neurogenic differentiation 4 associated with agonist
2) Confidence 0.01 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554861 Disease Relevance 0 Pain Relevance 0.66

General Comments

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