INT168906

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.75
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
oocytes 4
amygdala 2
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 13 99.44 Very High Very High Very High
Calcium channel 28 96.80 Very High Very High Very High
Pain 6 93.32 High High
cocaine 33 89.20 High High
Dopamine 6 88.76 High High
Inflammation 2 84.88 Quite High
Pyramidal cell 30 78.12 Quite High
Glutamate receptor 16 75.00 Quite High
Nucleus accumbens 4 57.88 Quite High
Glutamate 15 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 50 99.20 Very High Very High Very High
Pain 3 93.32 High High
Nociception 4 90.68 High High
INFLAMMATION 2 84.88 Quite High
Hypersensitivity 3 73.44 Quite High
Sprains And Strains 2 73.36 Quite High
Injury 2 63.20 Quite High
Anxiety Disorder 19 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The underlying cause for our findings is unclear, but altered OSS behavior in both mGluR5 KO and Het mice suggests that even subtle variation in mGluR5 expression is capable of altering reinforcement behavior in this paradigm.
Positive_regulation (variation) of Gene_expression (expression) of mGluR5 associated with targeted disruption
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.57 Pain Relevance 0.29
We also demonstrate significantly higher levels of mGluR5 expression in the right amygdala compared with the left under baseline conditions, suggesting a potential mechanism for right hemispheric lateralization of amygdala function in pain processing.
Positive_regulation (levels) of Gene_expression (expression) of mGluR5 in amygdala associated with pain and amygdala
2) Confidence 0.23 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 0.81 Pain Relevance 0.83
We found that DHPG application upregulated barium currents in oocytes expressing mGluR5 and Cav2.3 but not mGluR5 and Cav3.2, suggesting subunit selective modulation of R-type, but not T-type, calcium channels by mGluR5 activation with DHPG (Figure 9C and 9D).
Positive_regulation (upregulated) of Neg (not) Gene_expression (expressing) of mGluR5 in oocytes associated with calcium channel
3) Confidence 0.07 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.18 Pain Relevance 0.13
We found that DHPG application upregulated barium currents in oocytes expressing mGluR5 and Cav2.3 but not mGluR5 and Cav3.2, suggesting subunit selective modulation of R-type, but not T-type, calcium channels by mGluR5 activation with DHPG (Figure 9C and 9D).
Positive_regulation (upregulated) of Neg (not) Gene_expression (expressing) of mGluR5 in oocytes associated with calcium channel
4) Confidence 0.07 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.18 Pain Relevance 0.13

General Comments

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