INT16891

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Context Info
Confidence 0.37
First Reported 1985
Last Reported 1999
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.94
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH, GH1) extracellular region (GHRH, GH1) cell-cell signaling (GHRH)
GHRH (Homo sapiens)
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 3 99.82 Very High Very High Very High
Clonidine 14 98.92 Very High Very High Very High
Opioid 3 97.76 Very High Very High Very High
Fibrositis 14 93.84 High High
Potency 1 89.84 High High
Pain 2 81.72 Quite High
narcan 6 79.36 Quite High
Enkephalin 1 65.12 Quite High
agonist 1 34.16 Quite Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Fibromyalgia 13 93.84 High High
Syndrome 2 89.88 High High
Renal Failure 7 85.20 High High
Anaemia 6 84.36 Quite High
Fatigue 2 82.16 Quite High
Pain 1 81.72 Quite High
Uremia 1 69.84 Quite High
Congenital Anomalies 1 56.76 Quite High
Renal Disease 1 54.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The peak serum GH concentrations elicited by clonidine or GHRH were variable but one factor influencing the GH response to GHRH was the GH secretory status in the hour prior to the administration of the GHRH.
GHRH Regulation (response) of GH associated with clonidine
1) Confidence 0.37 Published 1990 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2147600 Disease Relevance 0 Pain Relevance 0.46
GH responses to GHRH were characterized by marked differences in single patients when compared with the control group.
GHRH Regulation (responses) of GH
2) Confidence 0.24 Published 1996 Journal Nephron Section Abstract Doc Link 8938679 Disease Relevance 0.83 Pain Relevance 0.31
Because one of the proposed mechanisms of action of GHRP is the inhibition of somatostatin (SS), we tested the effects of propranolol, which inhibits SS, on the GH responses to GHRH and GHRP.
GHRH Regulation (responses) of GH associated with somatostatin
3) Confidence 0.23 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.26
However, significant GH responses to TRH or hpGRF were observed when the interval between injections was either 120 or 240 min.
hpGRF Regulation (responses) of GH
4) Confidence 0.22 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926599 Disease Relevance 0 Pain Relevance 0
To gain further insight into the mechanisms leading to dysregulation of the GH-IGF-1 axis in these patients, we assessed 24-h spontaneous GH secretion, GH responses to GHRH, and IGF-1 and IGF binding protein (BP)-3 levels before and after 4 days treatment with human (h)GH.
GHRH Regulation (responses) of GH
5) Confidence 0.11 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10487713 Disease Relevance 1.11 Pain Relevance 0.51
We examined the in vitro effect of human growth hormone (hGH) on hormone placental production and the modulation by opioids of this function.
growth hormone Spec (examined) Regulation (effect) of hGH associated with opioid
6) Confidence 0.06 Published 1995 Journal Gynecol. Endocrinol. Section Abstract Doc Link 7502693 Disease Relevance 0 Pain Relevance 0.28

General Comments

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