INT168913

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.88
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1a) plasma membrane (Avpr1a) response to stress (Avpr1a)
signal transducer activity (Avpr1a)
Anatomy Link Frequency
neural 2
dorsal 1
body 1
ventral 1
Avpr1a (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 4 99.68 Very High Very High Very High
antagonist 99 99.36 Very High Very High Very High
Substantia nigra 28 98.84 Very High Very High Very High
Ventral tegmentum 24 98.12 Very High Very High Very High
Inflammation 2 93.96 High High
fluoxetine 248 90.72 High High
withdrawal 9 90.40 High High
Serotonin 42 90.20 High High
Spinal cord 3 89.36 High High
sSRI 40 87.12 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 123 99.96 Very High Very High Very High
Aggression 406 99.58 Very High Very High Very High
Embryonal Carcinoma 23 98.68 Very High Very High Very High
Nociception 2 94.44 High High
INFLAMMATION 2 93.96 High High
Attention Deficit Hyperactivity Disorder 48 83.12 Quite High
Mental Disorders 8 82.32 Quite High
Brain Injury 4 81.40 Quite High
Pain 2 81.24 Quite High
Intellectual Impairment 4 80.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that the neural circuitry underlying aggression compensates for the loss of the Avpr1a in the global Avpr1a KO.
Negative_regulation (loss) of Avpr1a in neural associated with targeted disruption and aggression
1) Confidence 0.43 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.43 Pain Relevance 0.04
If the level of general behavioral activity is normal with V1a receptor blockade and animals show normal sexual activity, a behavior with high emotional valence, it is reasonable to ask why the BOLD signal, a hemodynamic response to metabolically active areas, was blunted?
Negative_regulation (blockade) of V1a
2) Confidence 0.42 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.35 Pain Relevance 0.22
In wild-type mice, OXT-induced analgesia could be fully prevented by pretreatment with a V1AR but not an OTR antagonist.
Negative_regulation (prevented) of V1AR associated with antagonist and analgesia
3) Confidence 0.41 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554879 Disease Relevance 0.75 Pain Relevance 0.96
With V1a receptor blockade there was activation of the substantia nigra, ventral tegmental area and their afferent projects to the forebrain limbic cortex as well as the dorsal and ventral striatum.
Negative_regulation (blockade) of V1a in ventral associated with ventral tegmentum and substantia nigra
4) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.36 Pain Relevance 0.38
There is a large body of literature reporting blockade of vasopressin V1a receptors in a variety of animals suppresses offensive aggression [18].
Negative_regulation (blockade) of V1a in body associated with aggression
5) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.96 Pain Relevance 0.32
It is possible that the neural circuitry underlying aggression compensates for the loss of the Avpr1a in the global Avpr1a KO.
Negative_regulation (loss) of Avpr1a in neural associated with targeted disruption and aggression
6) Confidence 0.32 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.49 Pain Relevance 0.04
With V1a receptor blockade there was activation of the substantia nigra, ventral tegmental area and their afferent projects to the forebrain limbic cortex as well as the dorsal and ventral striatum.
Negative_regulation (blockade) of V1a in dorsal associated with ventral tegmentum and substantia nigra
7) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.36 Pain Relevance 0.38
Similar staining for V1aR was presented in the Fig. 3I.
Negative_regulation (presented) of V1aR
8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.19 Pain Relevance 0.11

General Comments

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