INT168913
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
It is possible that the neural circuitry underlying aggression compensates for the loss of the Avpr1a in the global Avpr1a KO. | |||||||||||||||
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If the level of general behavioral activity is normal with V1a receptor blockade and animals show normal sexual activity, a behavior with high emotional valence, it is reasonable to ask why the BOLD signal, a hemodynamic response to metabolically active areas, was blunted? | |||||||||||||||
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In wild-type mice, OXT-induced analgesia could be fully prevented by pretreatment with a V1AR but not an OTR antagonist. | |||||||||||||||
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With V1a receptor blockade there was activation of the substantia nigra, ventral tegmental area and their afferent projects to the forebrain limbic cortex as well as the dorsal and ventral striatum. | |||||||||||||||
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There is a large body of literature reporting blockade of vasopressin V1a receptors in a variety of animals suppresses offensive aggression [18]. | |||||||||||||||
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It is possible that the neural circuitry underlying aggression compensates for the loss of the Avpr1a in the global Avpr1a KO. | |||||||||||||||
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With V1a receptor blockade there was activation of the substantia nigra, ventral tegmental area and their afferent projects to the forebrain limbic cortex as well as the dorsal and ventral striatum. | |||||||||||||||
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Similar staining for V1aR was presented in the Fig. 3I. | |||||||||||||||
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General Comments
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