INT168913

Context Info Confidence 0.43 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 8 Disease Relevance 5.88 Pain Relevance 2.47

signal transduction (Avpr1a) plasma membrane (Avpr1a) response to stress (Avpr1a) signal transducer activity (Avpr1a)

Anatomy Link Frequency neural 2 dorsal 1 body 1 ventral 1 Avpr1a (Mus musculus)

Pain Link Frequency Relevance Heat analgesia 4 99.68 antagonist 99 99.36 Substantia nigra 28 98.84 Ventral tegmentum 24 98.12 Inflammation 2 93.96 fluoxetine 248 90.72 withdrawal 9 90.40 Serotonin 42 90.20 Spinal cord 3 89.36 sSRI 40 87.12

Disease Link Frequency Relevance Heat Targeted Disruption 123 99.96 Aggression 406 99.58 Embryonal Carcinoma 23 98.68 Nociception 2 94.44 INFLAMMATION 2 93.96 Attention Deficit Hyperactivity Disorder 48 83.12 Mental Disorders 8 82.32 Brain Injury 4 81.40 Pain 2 81.24 Intellectual Impairment 4 80.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is possible that the neural circuitry underlying aggression compensates for the loss of the Avpr1a in the global Avpr1a KO.

Negative_regulation (loss) of Avpr1a in neural associated with targeted disruption and aggression

1) Confidence 0.43 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.43 Pain Relevance 0.04

If the level of general behavioral activity is normal with V1a receptor blockade and animals show normal sexual activity, a behavior with high emotional valence, it is reasonable to ask why the BOLD signal, a hemodynamic response to metabolically active areas, was blunted?

Negative_regulation (blockade) of V1a

2) Confidence 0.42 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.35 Pain Relevance 0.22

In wild-type mice, OXT-induced analgesia could be fully prevented by pretreatment with a V1AR but not an OTR antagonist.

Negative_regulation (prevented) of V1AR associated with antagonist and analgesia

3) Confidence 0.41 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554879 Disease Relevance 0.75 Pain Relevance 0.96

With V1a receptor blockade there was activation of the substantia nigra, ventral tegmental area and their afferent projects to the forebrain limbic cortex as well as the dorsal and ventral striatum.

Negative_regulation (blockade) of V1a in ventral associated with ventral tegmentum and substantia nigra

4) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.36 Pain Relevance 0.38

There is a large body of literature reporting blockade of vasopressin V1a receptors in a variety of animals suppresses offensive aggression [18].

Negative_regulation (blockade) of V1a in body associated with aggression

5) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.96 Pain Relevance 0.32

It is possible that the neural circuitry underlying aggression compensates for the loss of the Avpr1a in the global Avpr1a KO.

Negative_regulation (loss) of Avpr1a in neural associated with targeted disruption and aggression

6) Confidence 0.32 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.49 Pain Relevance 0.04

With V1a receptor blockade there was activation of the substantia nigra, ventral tegmental area and their afferent projects to the forebrain limbic cortex as well as the dorsal and ventral striatum.

Negative_regulation (blockade) of V1a in dorsal associated with ventral tegmentum and substantia nigra

7) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.36 Pain Relevance 0.38

Similar staining for V1aR was presented in the Fig. 3I.

Negative_regulation (presented) of V1aR

8) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.19 Pain Relevance 0.11

General Comments

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