INT168914

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2009
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 5.51
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1a) plasma membrane (Avpr1a) response to stress (Avpr1a)
signal transducer activity (Avpr1a)
Anatomy Link Frequency
P19 2
chromaffin cells 2
pituitary 1
brain 1
forebrain 1
Avpr1a (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 250 99.76 Very High Very High Very High
medulla 48 99.50 Very High Very High Very High
Catecholamine 24 98.44 Very High Very High Very High
Dorsal horn 1 96.68 Very High Very High Very High
substantia gelatinosa 1 95.92 Very High Very High Very High
Spinal cord 3 93.36 High High
Eae 14 86.28 High High
Analgesic 3 82.32 Quite High
analgesia 4 81.64 Quite High
amygdala 9 80.00 Quite High
Disease Link Frequency Relevance Heat
Embryonal Carcinoma 161 99.06 Very High Very High Very High
Obesity 24 93.12 High High
Stress 641 91.20 High High
Targeted Disruption 484 89.36 High High
Sprains And Strains 98 88.36 High High
Anxiety Disorder 148 87.24 High High
Aggression 136 81.32 Quite High
Nociception 2 76.72 Quite High
INFLAMMATION 8 76.24 Quite High
Diabetes Mellitus 8 63.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, quantitative real-time reverse transcription (RT)-PCR revealed that V1AR but not OTR mRNA is abundantly expressed in mouse dorsal root ganglia, where it localizes to small- and medium-diameter cells as shown by single-cell RT-PCR.
Neg (not) Gene_expression (expressed) of V1AR in dorsal root ganglia
1) Confidence 0.75 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554879 Disease Relevance 0.54 Pain Relevance 0.90
Importantly, no differences were observed for Avpr1a, Avpr1b, Oxt or Oxtr (p>0.1) in the respective brain regions investigated (Table 3).
Neg (no) Gene_expression (observed) of Avpr1a in brain
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.72 Pain Relevance 0.08
The presence, however, of both Avpr1s in the human (Grazzini et al. 1999) adrenal medulla indicates a possible co-expression of Avpr1 receptors in some species.
Gene_expression (expression) of Avpr1 in adrenal medulla associated with medulla
3) Confidence 0.58 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.24 Pain Relevance 0.29
Affiliative behaviours such as pair bonding have been attributed to changes in Avpr1a expression patterns caused by microsatellite length variations in the 5?
Gene_expression (expression) of Avpr1a
4) Confidence 0.58 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.77 Pain Relevance 0
Intriguingly, both Avpr1a and Avpr1b genes are expressed in the forebrain olfactory system (Ostrowski et al. 1994; Hernando et al. 2001).
Gene_expression (expressed) of Avpr1a in forebrain
5) Confidence 0.58 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.63 Pain Relevance 0
The impact of microsatellite DNA sequences on receptor expression and behavioural phenotypes has been examined in studies on the effects of Avpr1a expression on social behaviour in voles.
Gene_expression (expression) of Avpr1a
6) Confidence 0.58 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.69 Pain Relevance 0
This suggests a possible overlap of function distinct from the roles already noted and may reflect the action of Avp originating from different sources (e.g. pituitary vs. local tissue release (Gallo-Payet and Guillon 1998)), although the medullary cell type that expresses Avpr1as has yet to be identified.
Gene_expression (expresses) of Avpr1as in pituitary
7) Confidence 0.45 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.18 Pain Relevance 0.26
The cortex expresses Avpr1a transcripts primarily in the zona glomerulosa (Guillon et al. 1995; Grazzini et al. 1996) where this receptor regulates steroid secretion in vitro (Grazzini et al. 1998).
Gene_expression (expresses) of Avpr1a in cortex
8) Confidence 0.45 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.54 Pain Relevance 0.18
The presence of Avpr1as in the adrenal cortex and Avpr1bs in the chromaffin cells of the medulla provides strong evidence of an independent modulatory role of each receptor in discrete regions of adrenal tissue.
Gene_expression (presence) of Avpr1as in chromaffin cells associated with medulla
9) Confidence 0.45 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.31 Pain Relevance 0.27
The peripheral distribution of the Avpr1b is much more restricted than that of the Avpr1a, which is ubiquitously expressed (Oshikawa et al. 2004; Fujiwara et al. 2007a).
Gene_expression (expressed) of Avpr1a
10) Confidence 0.45 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0 Pain Relevance 0.12
V1aR is present in ES D3 cells in the very early stages of cardiac development and is then strongly down-regulated [20].
Gene_expression (present) of V1aR
11) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.05 Pain Relevance 0.07
OTR and V1aR silencing by siRNA
Gene_expression (silencing) of V1aR
12) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.15 Pain Relevance 0
We observed that both V1aR antagonist as well as V1aR silencing partially blocked the cardiomyogenic effects of OT-GKR in EC P19 cells.
Gene_expression (silencing) of V1aR in P19 associated with antagonist and embryonal carcinoma
13) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.29 Pain Relevance 0.14
OT binding sites disclosed in the V1aR model are in total agreement with those reported by ?
Gene_expression (model) of V1aR
14) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0.03
To verify receptor function in the cardiomyogenesis of EC P19 cells, we used specific siRNA for OTR and V1aR silencing.
Gene_expression (silencing) of V1aR in P19 associated with embryonal carcinoma
15) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.19 Pain Relevance 0.12
V1aR was detected by goat polyclonal antibody C-20 (from Santa Cruz Biotech.
Gene_expression (detected) of V1aR
16) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0
We also analyzed the docking of OT-GKR and OT molecules in the 3-D human V1aR model molecules were similar binding affinity energies of -7,38±0.3 kJ/mol for OT-GKR and ?
Gene_expression (molecules) of V1aR
17) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox