INT168915

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 49
Total Number 53
Disease Relevance 20.53
Pain Relevance 7.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
smooth muscle 3
smooth muscle cells 3
P19 2
cardiomyocytes 2
somites 2
Oxtr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 742 99.92 Very High Very High Very High
agonist 317 99.60 Very High Very High Very High
Inflammation 462 99.12 Very High Very High Very High
Dorsal horn 1 96.16 Very High Very High Very High
substantia gelatinosa 1 95.40 Very High Very High Very High
bradykinin 160 95.36 Very High Very High Very High
Neuropeptide 37 95.08 Very High Very High Very High
Dismenorea 113 94.64 High High
Spinal cord 3 92.84 High High
antagonist 204 87.32 High High
Disease Link Frequency Relevance Heat
Embryonal Carcinoma 207 99.64 Very High Very High Very High
Asthma 1100 99.60 Very High Very High Very High
Targeted Disruption 246 99.56 Very High Very High Very High
Pyelonephritis 32 99.20 Very High Very High Very High
INFLAMMATION 496 99.12 Very High Very High Very High
Apoptosis 18 98.52 Very High Very High Very High
Increased Venous Pressure Under Development 44 98.28 Very High Very High Very High
Necrosis 99 97.84 Very High Very High Very High
Disease 136 97.60 Very High Very High Very High
Cancer 131 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, quantitative real-time reverse transcription (RT)-PCR revealed that V1AR but not OTR mRNA is abundantly expressed in mouse dorsal root ganglia, where it localizes to small- and medium-diameter cells as shown by single-cell RT-PCR.
Neg (not) Gene_expression (expressed) of OTR mRNA in dorsal root ganglia
1) Confidence 0.75 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554879 Disease Relevance 0.54 Pain Relevance 0.89
Here, we report the expression and function of oxytocin receptor in airway smooth muscle (both in human and mouse); more importantly, we also report that oxytocin receptor expression is affected by IL-13 and TNF?.
Gene_expression (expression) of oxytocin receptor in smooth muscle
2) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.87 Pain Relevance 0.35
The study of the molecular mechanisms regulating the expression of oxytocin receptor remains complex [42,43].
Gene_expression (expression) of oxytocin receptor
3) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.72 Pain Relevance 0.31
Using these models, investigators found that OXTR expression was downregulated by IL-1?
Gene_expression (expression) of OXTR
4) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.61 Pain Relevance 0.26
Since gender disparity in asthma is well recognized, studies could also address whether differential OXTR expression in the airways between men and women in part explains gender differences in asthma prevalence and morbidity or whether differential OXTR expression mediates asthma morbidity in pregnancy.


Spec (whether) Gene_expression (expression) of OXTR associated with asthma
5) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.47 Pain Relevance 0.04
Here, we report the expression and function of oxytocin receptor in airway smooth muscle (both in human and mouse); more importantly, we also report that oxytocin receptor expression is affected by IL-13 and TNF?.
Gene_expression (expression) of oxytocin receptor in smooth muscle
6) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.85 Pain Relevance 0.36
These data suggest that OXTR expression in lung occurs at low levels in the basal state (Table 1).


Gene_expression (expression) of OXTR in lung
7) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.15 Pain Relevance 0.05
Cytokines increase oxytocin receptor expression in HASMCs
Gene_expression (expression) of oxytocin receptor associated with cytokine
8) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.20 Pain Relevance 0.11
was more effective in increasing oxytocin receptor expression, oxytocin had no modulating effect on oxytocin-induced calcium responses in HASM cells.
Gene_expression (expression) of oxytocin receptor
9) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.15 Pain Relevance 0.24
Real time PCR was performed to assess whether oxytocin receptor expression was modulated by pro-inflammatory cytokines, TNF?
Spec (whether) Gene_expression (expression) of oxytocin receptor associated with inflammation and cytokine
10) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.10 Pain Relevance 0.10
As shown in Figure 2, expression of oxytocin receptor was significantly augmented in cells treated with either TNF?
Gene_expression (expression) of oxytocin receptor
11) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.26 Pain Relevance 0.18
To address this hypothesis, OXTR expression in ASM tissue derived from subjects with acute exacerbation would be required but such studies are beyond the scope of the current study.
Gene_expression (expression) of OXTR
12) Confidence 0.64 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.38 Pain Relevance 0.07
Since gender disparity in asthma is well recognized, studies could also address whether differential OXTR expression in the airways between men and women in part explains gender differences in asthma prevalence and morbidity or whether differential OXTR expression mediates asthma morbidity in pregnancy.


Gene_expression (expression) of OXTR associated with asthma
13) Confidence 0.56 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.49 Pain Relevance 0.07
Gene expression level of OXTR is expressed relative to 18 S and untreated samples in each stimulation study, respectively.
Gene_expression (expression) of OXTR
14) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.06 Pain Relevance 0.09
Our data does support the hypothesis that TNF and IL-13 have disparate effects on OXTR expression and that agonists with less efficacy at inducing calcium mobilization may be enhanced by increases in receptor expression rather than by processes that amplify downstream pro-contractile signaling pathways.
Gene_expression (expression) of OXTR associated with agonist
15) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.07 Pain Relevance 0.31
Cells were then incubated with either control isotype of goat polyclonal anti-human oxytocin receptor antibody (2 ?
Gene_expression (antibody) of oxytocin receptor
16) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.06 Pain Relevance 0.04
Gene expression level of OXTR is expressed relative to 18 S and untreated samples in each stimulation study, respectively.
Gene_expression (expressed) of OXTR
17) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.06 Pain Relevance 0.09
Levels of oxytocin receptor were expressed as the percent increase in mean fluorescence intensity over unstimulated cells.
Gene_expression (Levels) of oxytocin receptor
18) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.20 Pain Relevance 0.06
An increased gene transcription was detected by the real time PCR data demonstrating a rapid effect of these cytokines on oxytocin receptor expression.
Gene_expression (expression) of oxytocin receptor associated with cytokine
19) Confidence 0.55 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.22 Pain Relevance 0.24
As illustrated in Figure 3G, OTR staining with OTR antibody disclosed OTR expression in most EC P19 cells.
Gene_expression (expression) of OTR in P19 associated with embryonal carcinoma
20) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.19 Pain Relevance 0.12

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