INT168925

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.13
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
spinal cord 2
Oprm1 (Mus musculus)
Imraq2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 4 100.00 Very High Very High Very High
Spinal cord 6 96.28 Very High Very High Very High
Dorsal horn 2 95.48 Very High Very High Very High
Antinociceptive 6 93.76 High High
Opioid 2 91.72 High High
antagonist 2 91.44 High High
narcan 16 91.00 High High
agonist 2 89.56 High High
Morphine 6 89.24 High High
tolerance 6 87.76 High High
Disease Link Frequency Relevance Heat
Pain 4 64.48 Quite High
Substance Withdrawal Syndrome 4 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct injection of double-stranded adeno-associated virus type 2 (dsAAV2) with a mu-opioid receptor (MOR) mutant [S4.45(196)A], and a reporter protein (enhanced green fluorescent protein) into the spinal cord (S2/S3) dorsal horn region of ICR mice resulted in antinociceptive responses to systemic injection of opioid antagonist naloxone without altering the acute agonist morphine responses and no measurable tolerance or dependence development during subchronic naloxone treatment.
mu-opioid receptor Binding (injection) of dsAAV2 in spinal cord associated with narcan, dorsal horn, opioid receptor, antinociceptive, morphine, spinal cord, addiction, antagonist, tolerance, agonist and opioid
1) Confidence 0.04 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20554907 Disease Relevance 0.06 Pain Relevance 0.88
Direct injection of double-stranded adeno-associated virus type 2 (dsAAV2) with a mu-opioid receptor (MOR) mutant [S4.45(196)A], and a reporter protein (enhanced green fluorescent protein) into the spinal cord (S2/S3) dorsal horn region of ICR mice resulted in antinociceptive responses to systemic injection of opioid antagonist naloxone without altering the acute agonist morphine responses and no measurable tolerance or dependence development during subchronic naloxone treatment.
MOR Binding (injection) of dsAAV2 in spinal cord associated with narcan, dorsal horn, opioid receptor, antinociceptive, morphine, spinal cord, addiction, antagonist, tolerance, agonist and opioid
2) Confidence 0.04 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20554907 Disease Relevance 0.06 Pain Relevance 0.91

General Comments

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