INT168938

Context Info Confidence 0.40 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.10 Pain Relevance 0.19

plasma membrane (Igf1r)

Anatomy Link Frequency heart 2 Igf1r (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory marker 2 86.56 anesthesia 1 83.88 Inflammation 1 73.52

Disease Link Frequency Relevance Heat Diabetes Mellitus 9 99.72 INFLAMMATION 3 86.56 Apoptosis 2 77.08 Cardiovascular Disease 1 58.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

JNK and p42/p44 activity was significantly increased in the diabetic heart, while IGF-1R phosphorylation, IRS-2 tyrosine phosphorylation, and Akt activities were reduced.

Negative_regulation (reduced) of Phosphorylation (phosphorylation) of IGF-1R in heart associated with diabetes mellitus

1) Confidence 0.40 Published 2010 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 20555424 Disease Relevance 1.10 Pain Relevance 0.19

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