INT168939

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.01
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Igf1r)
Anatomy Link Frequency
heart 1
Igf1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory marker 2 99.30 Very High Very High Very High
anesthesia 1 71.48 Quite High
Inflammation 1 61.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 99.14 Very High Very High Very High
Apoptosis 2 98.80 Very High Very High Very High
Diabetes Mellitus 9 98.50 Very High Very High Very High
Cardiovascular Disease 1 46.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that diabetes activates multiple inflammatory markers in the heart, which then signal a decrease in the activities of key players in the insulin-signaling cascade, namely IGF-1R, IRS-2, and Akt, to regulate apoptosis.
Negative_regulation (decrease) of IGF-1R in heart associated with diabetes mellitus, inflammatory marker and apoptosis
1) Confidence 0.40 Published 2010 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 20555424 Disease Relevance 1.01 Pain Relevance 0.15

General Comments

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