INT168945

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.70
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
neurons 4
plasma 2
dentate gyrus 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 136 100.00 Very High Very High Very High
long-term potentiation 43 100.00 Very High Very High Very High
Hippocampus 42 100.00 Very High Very High Very High
dorsal root ganglion 8 99.60 Very High Very High Very High
antidepressant 22 99.52 Very High Very High Very High
Dorsal horn 3 99.30 Very High Very High Very High
Painful diabetic neuropathy 2 95.44 Very High Very High Very High
Spinal cord 40 80.80 Quite High
Stimulus evoked pain 18 70.60 Quite High
fluoxetine 33 63.88 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 99.60 Very High Very High Very High
Diabetes Mellitus 6 97.12 Very High Very High Very High
Diabetic Neuropathy 2 95.44 Very High Very High Very High
Hypersensitivity 18 70.60 Quite High
Pain 54 69.92 Quite High
Urological Neuroanatomy 3 55.60 Quite High
Neuropathic Pain 31 53.88 Quite High
INFLAMMATION 7 41.16 Quite Low
Amnesia 4 37.64 Quite Low
Aids-related Complex 14 31.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the deep dorsal horn (lamina III and IV), considerable increased intensity of BDNF-IR was also observed in the neurons (Table 1).
Positive_regulation (increased) of BDNF-IR Binding (intensity) of in neurons associated with dorsal horn and bdmf
1) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 0.38 Pain Relevance 1.01
The main findings of the present study are: (1) a biphasic activation of hippocampal mTOR signaling is associated with IA training and is required for its memory formation; (2) activation of the mTOR cascade in the dorsal hippocampus is initiated by BDNF; (3) previously synthesized BDNF is rapidly released immediately after IA training whereas around 3 h after training, new synthesis of BDNF protein is needed for LTM formation; (4) learning related BDNF/mTOR cascade activation after training induces GluR1 expression in hippocampal synaptic plasma membranes; and (5) GluR1 translation during training or 3 h later is required for IA memory consolidation.
Positive_regulation (required) of BDNF Binding (initiated) of in plasma associated with hippocampus
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05
Increased BDNF activity in these neurons likely contributes to the reduction in Kv channel function through TrkB receptor stimulation in painful diabetic neuropathy.
Positive_regulation (Increased) of BDNF Binding (activity) of in neurons associated with painful diabetic neuropathy
3) Confidence 0.43 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20557422 Disease Relevance 1.26 Pain Relevance 0.51
Several events associated with BDNF-LTP in the dentate gyrus are induced by chronic antidepressant treatment.
Positive_regulation (induced) of BDNF-LTP Binding (associated) of in dentate gyrus associated with antidepressant and long-term potentiation
4) Confidence 0.40 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.06 Pain Relevance 0.57

General Comments

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