INT168959

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.70
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CAV3) Golgi apparatus (CAV3) cytoplasm (CAV3)
Anatomy Link Frequency
muscle 2
muscle cells 1
CAV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 52 100.00 Very High Very High Very High
opioid receptor 4 93.20 High High
Enkephalin 4 91.60 High High
cytokine 5 71.40 Quite High
metalloproteinase 6 60.64 Quite High
Inflammation 3 45.92 Quite Low
backache 8 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 62 81.88 Quite High
Stress 15 80.48 Quite High
Adenocarcinoma 1 64.32 Quite High
INFLAMMATION 3 45.92 Quite Low
Osteoarthritis 3 27.96 Quite Low
Atherosclerotic Plaque 1 25.88 Quite Low
Low Back Pain 8 5.00 Very Low Very Low Very Low
Myeloid Leukemia 3 5.00 Very Low Very Low Very Low
Retinoblastoma 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contraction was measured in muscle cells transfected with CAV3 mRNA or clathrin heavy-chain small-interfering RNA (siRNA).
Gene_expression (transfected) of CAV3 in muscle cells
1) Confidence 0.65 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.40
CAV-3 siRNA reduced CAV-3 protein expression, decreased CCK-8-induced contraction, and accumulated CCK-1R in the caveolae.
Gene_expression (expression) of CAV-3 protein associated with cholecystokinin
2) Confidence 0.62 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.63
We found that impaired muscle contraction in GBs with cholesterol stones is due to high caveolar levels of cholesterol that inhibits pCAV-3 generation.
Gene_expression (generation) of pCAV-3 in muscle
3) Confidence 0.42 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.48
Pretreatment with cholesterol-rich liposomes inhibited the transfer of CCK-1R and of CAV-3 in the endosomes by blocking CAV-3 phosphorylation. 4-Amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (inhibitor of tyrosine kinase) reproduced these effects by blocking pCAV-3 formation, increasing CAV-3 and CCK-1R sequestration in the caveolae and impairing CCK-8-induced contraction.
Gene_expression (transfer) of CAV-3 associated with cholecystokinin
4) Confidence 0.42 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.57
Expression of caveolin-3 is muscle-specific, whereas caveolin-1 and caveolin-2 are coexpressed in many cell types [26].
Gene_expression (Expression) of caveolin-3 in muscle
5) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.70 Pain Relevance 0.12

General Comments

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