INT168960

Context Info Confidence 0.30 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 1.05

cell differentiation (CAV3) Golgi apparatus (CAV3) cytoplasm (CAV3)

CAV3 (Homo sapiens)

Pain Link Frequency Relevance Heat Cholecystokinin 26 100.00 opioid receptor 2 90.00 Enkephalin 2 88.40

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Caveolar cholesterol increases the caveolar sequestration of CAV-3 and CCK-1R caused by their reduced recycling to the PM.

CAV-3 Binding (recycling) of associated with cholecystokinin

1) Confidence 0.30 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.44

Pretreatment with cholesterol-rich liposomes inhibited the transfer of CCK-1R and of CAV-3 in the endosomes by blocking CAV-3 phosphorylation. 4-Amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (inhibitor of tyrosine kinase) reproduced these effects by blocking pCAV-3 formation, increasing CAV-3 and CCK-1R sequestration in the caveolae and impairing CCK-8-induced contraction.

pCAV-3 Binding (formation) of associated with cholecystokinin

2) Confidence 0.26 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.61

General Comments

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