INT168964

Context Info Confidence 0.47 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0 Pain Relevance 1.68

cell differentiation (CAV3) Golgi apparatus (CAV3) cytoplasm (CAV3)

Anatomy Link Frequency muscle 2 CAV3 (Homo sapiens)

Pain Link Frequency Relevance Heat Cholecystokinin 39 100.00 opioid receptor 3 93.56 Enkephalin 3 91.96

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CAV-3 siRNA reduced CAV-3 protein expression, decreased CCK-8-induced contraction, and accumulated CCK-1R in the caveolae.

Negative_regulation (reduced) of Gene_expression (expression) of CAV-3 protein associated with cholecystokinin

1) Confidence 0.47 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.63

Pretreatment with cholesterol-rich liposomes inhibited the transfer of CCK-1R and of CAV-3 in the endosomes by blocking CAV-3 phosphorylation. 4-Amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (inhibitor of tyrosine kinase) reproduced these effects by blocking pCAV-3 formation, increasing CAV-3 and CCK-1R sequestration in the caveolae and impairing CCK-8-induced contraction.

Negative_regulation (inhibited) of Gene_expression (transfer) of CAV-3 associated with cholecystokinin

2) Confidence 0.30 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.57

We found that impaired muscle contraction in GBs with cholesterol stones is due to high caveolar levels of cholesterol that inhibits pCAV-3 generation.

Negative_regulation (inhibits) of Gene_expression (generation) of pCAV-3 in muscle

3) Confidence 0.30 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.48

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