INT16897

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Context Info
Confidence 0.77
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.46
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GHSR) signal transducer activity (GHSR)
Anatomy Link Frequency
hypothalamus 1
pituitary 1
GHSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 81.04 Quite High
Somatostatin 9 74.00 Quite High
qutenza 2 64.72 Quite High
Potency 1 64.20 Quite High
vagus nerve 4 57.12 Quite High
Opioid 1 41.60 Quite Low
Enkephalin 1 39.48 Quite Low
Neuropeptide 1 32.96 Quite Low
Clonidine 1 25.00 Low Low
tolerance 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypopituitarism 2 91.44 High High
Growth Hormone Deficiency 1 89.68 High High
Stress 4 71.28 Quite High
Peptic Ulcer 2 70.08 Quite High
Diabetes Mellitus 30 28.20 Quite Low
Disease 6 26.32 Quite Low
Hypoglycemia 3 25.00 Low Low
Targeted Disruption 54 5.00 Very Low Very Low Very Low
Obesity 49 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since GHRP can produce a greater maximal GH response than GHRH, mechanisms other than release of endogenous GHRH must be involved.
Gene_expression (produce) of GHRP
1) Confidence 0.77 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.14
GHSR1b mRNA is as widely expressed as ghrelin, whereas GHSR1a gene expression is concentrated in the hypothalamus-pituitary unit, although it is also distributed in other central and peripheral tissues [15].
Gene_expression (expressed) of GHSR in hypothalamus
2) Confidence 0.58 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0 Pain Relevance 0
The heptapeptide growth hormone-releasing peptide-1 (GHRP-1), one of a series of recently synthesized small growth hormone (GH)-releasing peptides, was administered as an iv bolus (1 microgram/kg) to 15 (six prepubertal, nine pubertal) short but healthy children and adolescents and to eight juvenile patients with pituitary insufficiency (four with isolated growth hormone deficiency, two with multiple pituitary hormone deficiencies, one with partial GH deficiency and one with GH-releasing hormone (GHRH) deficiency).
Gene_expression (synthesized) of GHRP-1 in pituitary associated with growth hormone deficiency and hypopituitarism
3) Confidence 0.39 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8279223 Disease Relevance 0.18 Pain Relevance 0
However, in addition to stimulating GH secretion, ghrelin possesses several other endocrine and extraendocrine biological activities that are explained by the widespread distribution of ghrelin and GHS-R1a expression.
Gene_expression (expression) of GHS-R1a
4) Confidence 0.38 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 16370568 Disease Relevance 0.14 Pain Relevance 0.13
However, in addition to stimulating GH secretion, ghrelin possesses several other endocrine and extraendocrine biological activities that are explained by the widespread distribution of ghrelin and GHS-R1a expression.
Gene_expression (expression) of GHS-R1a
5) Confidence 0.33 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 16370568 Disease Relevance 0.14 Pain Relevance 0.13
It has been shown that the ghrelin peptide with its receptor regulates gastrointestinal motility in rodents and the expression of GHSR in the human gastrointestinal tract indicates that ghrelin plays a role in gastrointestinal motility in humans as well [57-59].
Gene_expression (expression) of GHSR
6) Confidence 0.24 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2117022 Disease Relevance 0 Pain Relevance 0

General Comments

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