INT16898

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.76
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GHSR) signal transducer activity (GHSR)
Anatomy Link Frequency
thyrotrope 1
nerve 1
neurons 1
lactotrope 1
GHSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
COX-2 inhibitor 2 85.96 High High
imagery 6 79.92 Quite High
Inflammation 7 68.64 Quite High
cINOD 1 63.88 Quite High
agonist 4 62.16 Quite High
Potency 2 54.08 Quite High
nud 1 53.44 Quite High
Pain 1 52.40 Quite High
Somatostatin 6 39.84 Quite Low
Disease Link Frequency Relevance Heat
Hyperplasia 2 95.32 Very High Very High Very High
Hypothyroidism 6 94.56 High High
Appetite Loss 87 87.40 High High
Cancer 66 87.04 High High
Frailty 9 86.48 High High
Obesity 1 78.48 Quite High
Anorexia 2 76.56 Quite High
Gastrointestinal Neoplasms 2 74.32 Quite High
INFLAMMATION 9 68.64 Quite High
Pancreatic Cancer 7 59.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2), a hexapeptide derived from enkephalin, has been shown to have GH-releasing activity in man and several animal species.
Localization (releasing) of GH-releasing peptide associated with enkephalin
1) Confidence 0.74 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.13
GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2), a hexapeptide derived from enkephalin, has been shown to have GH-releasing activity in man and several animal species.
Localization (releasing) of GH-releasing associated with enkephalin
2) Confidence 0.74 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.13
Ghrelin induced Ca2+ transients in one third of the myenteric neurons, involving release of Ca2+ from intracellular stores and direct GHS-receptor activation.
Localization (release) of GHS-receptor in neurons
3) Confidence 0.57 Published 2008 Journal Verh. K. Acad. Geneeskd. Belg. Section Abstract Doc Link 18630723 Disease Relevance 0.11 Pain Relevance 0.18
Not only does ghrelin stimulate GH secretion (via the GH secretagogue-1a (GHS-1a) receptor) but it also promotes food intake (via the orexigenic NPY system) and decreases sympathetic nerve activity.
Localization (secretagogue) of GHS-1a in nerve
4) Confidence 0.25 Published 2010 Journal Indian Journal of Palliative Care Section Body Doc Link PMC3012235 Disease Relevance 1.12 Pain Relevance 0.20
The most potent peptide reported, GH releasing peptide-6 (GHRP-6), was shown to release GH by a different pathway to the known signalling peptide, growth hormone releasing hormone (GHRH).
Localization (releasing) of releasing peptide-6
5) Confidence 0.01 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989584 Disease Relevance 0 Pain Relevance 0.10
The most potent peptide reported, GH releasing peptide-6 (GHRP-6), was shown to release GH by a different pathway to the known signalling peptide, growth hormone releasing hormone (GHRH).
Localization (release) of releasing peptide-6
6) Confidence 0.01 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989584 Disease Relevance 0 Pain Relevance 0.10
GH secretion after growth hormone-releasing hormone (GHRH), growth hormone releasing peptide-6 (GHRP-6) and after combined administration of both peptides was studied in a patient with lactotrope and thyrotrope hyperplasia due to primary hypothyroidism.
Localization (releasing) of releasing peptide-6 in thyrotrope associated with hypothyroidism and hyperplasia
7) Confidence 0.01 Published 1996 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 8961133 Disease Relevance 0.26 Pain Relevance 0.04
GH secretion after growth hormone-releasing hormone (GHRH), growth hormone releasing peptide-6 (GHRP-6) and after combined administration of both peptides was studied in a patient with lactotrope and thyrotrope hyperplasia due to primary hypothyroidism.
Localization (releasing) of releasing peptide-6 in lactotrope associated with hypothyroidism and hyperplasia
8) Confidence 0.00 Published 1996 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 8961133 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox