INT168983

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.40
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nrg1) extracellular space (Nrg1) cell morphogenesis (Nrg1)
plasma membrane (Nrg1) cytoplasm (Nrg1)
Anatomy Link Frequency
radial 2
Sensory neurons 1
monocytes 1
peripheral nerves 1
cleavage 1
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 7 99.36 Very High Very High Very High
unmyelinated 6 99.28 Very High Very High Very High
c fibre 3 98.76 Very High Very High Very High
nav1.8 3 98.12 Very High Very High Very High
sodium channel 5 92.64 High High
rheumatoid arthritis 30 92.20 High High
Central nervous system 10 92.20 High High
Inflammation 22 91.28 High High
Peripheral nervous system 13 88.28 High High
cytokine 9 87.52 High High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 16 99.98 Very High Very High Very High
Pain 7 99.36 Very High Very High Very High
Nociception 4 95.72 Very High Very High Very High
Rheumatoid Arthritis 30 92.20 High High
Disease 66 91.76 High High
INFLAMMATION 27 91.28 High High
Schizophrenia 12 86.96 High High
Demyelinating Disease 21 85.60 High High
Increased Venous Pressure Under Development 5 78.60 Quite High
Congenital Anomalies 8 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At baseline, deletion of NRG1 and DISC1 each reduced thermal pain sensitivity, while deletion of COMT increased pain sensitivity.
Negative_regulation (deletion) of NRG1 associated with pain
1) Confidence 0.43 Published 2010 Journal Brain Res. Section Abstract Doc Link 20561508 Disease Relevance 1.27 Pain Relevance 0.53
Sensory neurons from Type III Nrg1 mutant mice exhibit deficits of the surface expression of ?
Negative_regulation (deficits) of Nrg1 in Sensory neurons
2) Confidence 0.42 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
In E24 MAM treated ferrets, NRG1 is reduced and treatment with recombinant NRG1 realigns radial glial morphology [28].
Negative_regulation (reduced) of NRG1 in radial
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Radial glial disruption in E24 MAM treated cortex is likely to be caused in part by reduction of NRG1, because exogenous replacement results in realignment in E24 MAM treated organotypic slices [28].
Negative_regulation (reduction) of NRG1 in cortex
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.12 Pain Relevance 0.03
In these mice, neuregulin 1 type III was also inactivated in small myelinated A?
Negative_regulation (inactivated) of neuregulin 1 type III
5) Confidence 0.26 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.07 Pain Relevance 0.39
Genetic inactivation of neuregulin 1 type III in small-calibre unmyelinated C-fibres, using Nav1.8-Cre mice, results in aberrant Remak fibres that contain abnormally large numbers of axons, and the altered morphology is reflected in a reduced response to noxious pressure stimulation [15].
Negative_regulation (inactivation) of neuregulin 1 type III associated with c fibre, nav1.8 and unmyelinated
6) Confidence 0.26 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.09 Pain Relevance 0.41
Lack of calcineurin B prevents neuregulin-induced dephosphorylation and activation of NFAT c3 and c4.
Negative_regulation (prevents) of neuregulin in NFAT
7) Confidence 0.26 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0 Pain Relevance 0.03
and NRG1, the cleavage of IL-1R2 was not reduced in BACE deficient cells.
Neg (not) Negative_regulation (reduced) of NRG1 in cleavage
8) Confidence 0.26 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.07 Pain Relevance 0.04
In these conditions, the effect of NRG1 on vimentin+ radial glia was significantly reduced when Pi3K was inhibited.
Negative_regulation (effect) of NRG1 in radial
9) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
They also were affected by hypomyelination of peripheral nerves and had altered neurological behaviors such as reduced grip strength and elevated pain sensitivity, likely due to the deficiency of neuregulin processing in the absence of BACE1, as neuregulin 1 is another substrate of BACE1 [85,86].
Negative_regulation (deficiency) of neuregulin in peripheral nerves associated with pain
10) Confidence 0.03 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.68 Pain Relevance 0.19
We recently identified apolipoprotein A-I (apoA-I) as a specific inhibitor of contact-mediated activation of monocytes [5].
Negative_regulation (inhibitor) of A-I in monocytes associated with disorder of lipid metabolism
11) Confidence 0.01 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 1.09 Pain Relevance 0.37

General Comments

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