INT16899

Context Info Confidence 0.13 First Reported 1991 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.28 Pain Relevance 0.85

nucleus (SHOX)

SHOX (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 10 100.00 agonist 1 99.10 Clonidine 1 98.30 Potency 2 93.72 Enkephalin 2 69.00

Disease Link Frequency Relevance Heat Aging 5 85.08 Cardiovascular Disorder Under Development 1 5.00 Reprotox - General 2 1 5.00 Appetite Loss 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because one of the proposed mechanisms of action of GHRP is the inhibition of somatostatin (SS), we tested the effects of propranolol, which inhibits SS, on the GH responses to GHRH and GHRP.

Negative_regulation (inhibition) of SS associated with somatostatin

1) Confidence 0.13 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.26

Because one of the proposed mechanisms of action of GHRP is the inhibition of somatostatin (SS), we tested the effects of propranolol, which inhibits SS, on the GH responses to GHRH and GHRP.

Negative_regulation (inhibits) of SS associated with somatostatin

2) Confidence 0.09 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.26

In old dogs, a combination of GHRH and clonidine (CLO), an alpha(2)-adrenoceptor agonist, reportedly acting via GHRH stimulation and SS inhibition, is the most effective stimulus to rejuvenate the apulsatile GH secretion.

Negative_regulation (inhibition) of SS associated with somatostatin, agonist and clonidine

3) Confidence 0.02 Published 2002 Journal Neurobiol. Aging Section Abstract Doc Link 12392795 Disease Relevance 0.28 Pain Relevance 0.32

General Comments

This test has worked.