INT168990

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.14
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) Golgi apparatus (Pla2g4a) endoplasmic reticulum (Pla2g4a)
nucleus (Pla2g4a) cytoplasm (Pla2g4a)
Anatomy Link Frequency
macrophages 2
Pla2g4a (Mus musculus)
Pain Link Frequency Relevance Heat
Stimulus evoked pain 3 95.68 Very High Very High Very High
Inflammation 27 92.24 High High
Pain 3 78.64 Quite High
cINOD 4 75.44 Quite High
IPN 1 75.00 Quite High
hyperexcitability 1 67.60 Quite High
cytokine 8 40.08 Quite Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 41 97.24 Very High Very High Very High
Pain 4 95.68 Very High Very High Very High
Hypersensitivity 4 95.28 Very High Very High Very High
INFLAMMATION 29 92.24 High High
Hyperplasia 1 86.76 High High
Death 4 83.12 Quite High
Colon Cancer 4 79.68 Quite High
Pressure And Volume Under Development 1 78.28 Quite High
Inflammatory Pain 1 75.00 Quite High
Intestinal Cancer 1 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulating P2X4R in macrophages triggers calcium influx and p38 MAPK phosphorylation, resulting in cytosolic PLA2 (cPLA2) activation and COX-dependent release of PGE2.
Positive_regulation (resulting) of Positive_regulation (activation) of cPLA2 in macrophages
1) Confidence 0.43 Published 2010 Journal EMBO J. Section Abstract Doc Link 20562826 Disease Relevance 1.13 Pain Relevance 0.86
This results in downstream activation of cPLA2 and release of the prostaglandin precursor arachadonic acid, a potential substrate for COX-2 now known to be induced as an important element of p53 inhibition by MIF.
Positive_regulation (results) of Positive_regulation (activation) of cPLA2
2) Confidence 0.18 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.01 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox