INT169000

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.24
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
MIR15B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 94.08 High High
Morphine 6 93.24 High High
Central nervous system 1 75.00 Quite High
Pain 1 46.56 Quite Low
anesthesia 1 45.32 Quite Low
opiate 1 40.96 Quite Low
metalloproteinase 2 5.88 Low Low
aspirin 7 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
palliative 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 646 99.84 Very High Very High Very High
Colon Cancer 139 99.84 Very High Very High Very High
Chronic Lymphoid Leukemia 33 99.84 Very High Very High Very High
Disease 36 96.56 Very High Very High Very High
Apoptosis 88 94.92 High High
Stress 21 94.92 High High
INFLAMMATION 13 94.08 High High
Necrosis 3 89.76 High High
Infection 6 88.84 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, differentially expressed miRNAs (hsa-miR-15b and 181-b) may have a potential role in regulating these processes.
Gene_expression (expressed) of miR-15b
1) Confidence 0.65 Published 2010 Journal J. Cell. Biochem. Section Abstract Doc Link 20564181 Disease Relevance 0.60 Pain Relevance 0.63
The expression of hsa-miR-15b was overexpressed by nearly 1.5-fold (Median: 1.30 vs. 0.89, p = 0.0278) (Figure 1A).
Gene_expression (expression) of hsa-miR-15b
2) Confidence 0.34 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.55 Pain Relevance 0
Among the ten miRNAs, hsa-miR-15b (p = 0.0278), hsa-miR-181b (p = 0.0002), hsa-miR-191 (p = 0.0264) and hsa-miR-200c (p = 0.0017) were significantly over-expressed in tumors compared to normal colorectal samples.
Gene_expression (expressed) of hsa-miR-15b associated with cancer
3) Confidence 0.34 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.60 Pain Relevance 0
The expression of hsa-miR-15b, hsa-miR-181b, hsa-miR-191 and hsa-miR-200c were significantly over-expressed in colorectal cancer patients and they may be associated with the development of the disease.
Gene_expression (expression) of hsa-miR-15b associated with colon cancer and disease
4) Confidence 0.34 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.82 Pain Relevance 0
Ten miRNAs (hsa-let-7b, hsa-let-7g, hsa-miR-15b, hsa-miR-181b, hsa-miR-191, hsa-miR-200c, hsa-miR-26a, hsa-miR-27a, hsa-miR-30a-5p and hsa-miR-30c) were evaluated for their potential prognostic value in colorectal cancer patients.
Gene_expression (hsa) of hsa-miR-15b associated with colon cancer
5) Confidence 0.29 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.52 Pain Relevance 0
The expression of hsa-miR-15b was overexpressed by nearly 1.5-fold (Median: 1.30 vs. 0.89, p = 0.0278) (Figure 1A).
Gene_expression (overexpressed) of hsa-miR-15b
6) Confidence 0.26 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.55 Pain Relevance 0
The expression of hsa-miR-15b, hsa-miR-181b, hsa-miR-191 and hsa-miR-200c were significantly over-expressed in colorectal cancer patients and they may be associated with the development of the disease.
Gene_expression (expressed) of hsa-miR-15b associated with colon cancer and disease
7) Confidence 0.26 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.84 Pain Relevance 0
We found that lipopolysaccharide (LPS) stimulation of mouse Raw 264.7 macrophages resulted in the upregulation of miR-155 and downregulation of miR-125b levels.
Gene_expression (levels) of miR-125b in macrophages
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 1.02 Pain Relevance 0.04
In a cell line with high bcl-2 and no expression of these miRNAs, they found that transfection of miR-15 and miR-16 caused a significant reduction in bcl-2 expression.
Gene_expression (transfection) of miR-15
9) Confidence 0.08 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.03 Pain Relevance 0
They found that the levels of miR-15 and miR-16 are inversely correlated with bcl-2 expression in CLL cells.
Gene_expression (levels) of miR-15 associated with chronic lymphoid leukemia
10) Confidence 0.08 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.05 Pain Relevance 0
They found that the levels of miR-15 and miR-16 are inversely correlated with bcl-2 expression in CLL cells.
Gene_expression (expression) of miR-15 associated with chronic lymphoid leukemia
11) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 1.06 Pain Relevance 0
-catenin control of the intensity and spatial pattern of Nodal responsiveness is thought to be regulated by miR-15 and miR-16 expression [93].
Gene_expression (expression) of miR-15
12) Confidence 0.02 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.15 Pain Relevance 0
Using these algorithms, we performed prediction analysis for the target genes of the differentially expressed miRNAs identified in microarray (miR-124, miR-125a-5p, miR-125b, miR-126, miR-145, miR-151-3p, miR-524-5p, miR-516b, miR-744 and miR-96).
Gene_expression (miR-151-3p) of miR-125b
13) Confidence 0.01 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.46 Pain Relevance 0

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