INT169046

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 1.49
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

sulfur compound metabolic process (Sult4a1) lipid metabolic process (Sult4a1) cytoplasm (Sult4a1)
Anatomy Link Frequency
neurons 4
brain 3
neuronal precursors 1
synaptic vesicles 1
gustatory neurons 1
Sult4a1 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 294 99.42 Very High Very High Very High
Action potential 28 98.52 Very High Very High Very High
sodium channel 10 98.36 Very High Very High Very High
potassium channel 2 96.00 Very High Very High Very High
Nerve growth factor 36 95.84 Very High Very High Very High
opioid receptor 15 94.08 High High
anticonvulsant 14 93.72 High High
nociceptor 12 90.80 High High
Enkephalin 5 88.52 High High
Pain 22 86.12 High High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 5 86.96 High High
Pain 24 86.12 High High
Ganglion Cysts 264 85.24 High High
Schizophrenia 5 84.36 Quite High
Neuropathic Pain 6 74.96 Quite High
Injury 2 72.00 Quite High
Apoptosis 18 62.84 Quite High
Epilepsy 2 61.76 Quite High
Nociception 8 59.28 Quite High
Depression 2 55.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulfotransferase 4A1 (SULT4A1) is a novel cytosolic sulfotransferase that is primarily expressed in the brain.
Gene_expression (expressed) of Sulfotransferase 4A1 in brain
1) Confidence 0.71 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.15 Pain Relevance 0
Sulfotransferase 4A1 (SULT4A1) is a novel cytosolic sulfotransferase that is primarily expressed in the brain.
Gene_expression (expressed) of SULT4A1 in brain
2) Confidence 0.71 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.15 Pain Relevance 0
However, the alteration produced by NST on the time constant of repolarization could also indicate a possible involvement of voltage-gated potassium channels as it was verified by Pisciotta and Prestipino [22] when fenitoine was used.
Gene_expression (produced) of NST associated with potassium channel
3) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2952823 Disease Relevance 0.29 Pain Relevance 0.89
That amplitude reduction produced by NST is shown in Figure 3.


Gene_expression (produced) of NST
4) Confidence 0.66 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2952823 Disease Relevance 0.31 Pain Relevance 0.90
The CREs are located within 100 base pairs of the major transcription start site and are also present in the same region of the human SULT4A1 promoter.
Gene_expression (present) of SULT4A1
5) Confidence 0.61 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.17 Pain Relevance 0.12
Regulation of mouse brain-selective sulfotransferase sult4a1 by cAMP response element-binding protein and activating transcription factor-2.
Gene_expression (sulfotransferase) of sult4a1 in brain
6) Confidence 0.61 Published 2010 Journal Mol. Pharmacol. Section Title Doc Link 20571078 Disease Relevance 0.16 Pain Relevance 0
We also show that DAMGO treatment increases Sult4a1 mRNA and protein levels in primary mouse neurons.
Gene_expression (levels) of Sult4a1 in neurons
7) Confidence 0.55 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.06 Pain Relevance 0.23
In addition to Phox2b, neurons of the NST also express another homeobox gene, Tlx3 [131].
Gene_expression (express) of NST in neurons
8) Confidence 0.20 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0.16
Development of post-synaptic neurons in the NST
Gene_expression (neurons) of NST in neurons
9) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0.08
Thus, it is yet to be determined whether BDNF-dependent gustatory neurons reach the NST in the absence of functional BDNF.
Gene_expression (reach) of NST in gustatory neurons associated with bdmf
10) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.06 Pain Relevance 0.32
This transcription factor is expressed by NST neurons and neuronal precursors [21,130] and the NST does not form in its absence [21].
Gene_expression (neurons) of NST in neuronal precursors
11) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0.03
The first synaptic thickenings in the rostral NST are detectable at E17, and the first synaptic vesicles are observed at E19 [120].
Gene_expression (detectable) of NST in synaptic vesicles
12) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.14 Pain Relevance 0.07
This transcription factor is expressed by NST neurons and neuronal precursors [21,130] and the NST does not form in its absence [21].
Gene_expression (neurons) of NST in neurons
13) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0.03

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