INT169047

Context Info Confidence 0.36 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 2 Disease Relevance 0.31 Pain Relevance 0.19

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)

Anatomy Link Frequency brain 2 Atf2 (Mus musculus)

Pain Link Frequency Relevance Heat Enkephalin 2 88.32 opioid receptor 6 80.64

Disease Link Frequency Relevance Heat Schizophrenia 2 86.00 Neurodegenerative Disease 2 79.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Overexpression of CREB or ATF-2 increased not only reporter promoter activity but also endogenous Sult4a1 mRNA levels in Neuro2a cells.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ATF-2

1) Confidence 0.36 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.14 Pain Relevance 0.19

Regulation of mouse brain-selective sulfotransferase sult4a1 by cAMP response element-binding protein and activating transcription factor-2.

Positive_regulation (sulfotransferase) of Gene_expression (sulfotransferase) of cAMP response element-binding protein in brain

2) Confidence 0.36 Published 2010 Journal Mol. Pharmacol. Section Title Doc Link 20571078 Disease Relevance 0.17 Pain Relevance 0

General Comments

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