INT169048

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.11 Pain Relevance 0.24

sulfur compound metabolic process (Sult4a1) nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2) lipid metabolic process (Sult4a1) cytoplasm (Sult4a1)

Anatomy Link Frequency receptor cells 2 Atf2 (Mus musculus) Sult4a1 (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 3 99.14 Enkephalin 1 96.36

Disease Link Frequency Relevance Heat Neurodegenerative Disease 1 59.56 Schizophrenia 1 52.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Moreover, [d-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO) treatment increased both reporter promoter activity and Sult4a1 levels in mu-opioid receptor expressing Neuro2a/mu-opioid receptor cells, and EMSAs showed this to be due to increased binding of CREB and ATF-2 to the Sult4a1 promoter.

Positive_regulation (increased) of ATF-2 Binding (binding) of Sult4a1 in receptor cells associated with opioid receptor and enkephalin

1) Confidence 0.38 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.11 Pain Relevance 0.24

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