INT169057

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.79
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (VEGFC) signal transduction (VEGFC) extracellular space (VEGFC)
extracellular region (VEGFC)
Anatomy Link Frequency
macrophages 1
blood 1
connective tissue 1
VEGFC (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 6 97.16 Very High Very High Very High
Potency 1 93.56 High High
Bioavailability 1 90.80 High High
Inflammation 102 87.84 High High
cytokine 49 84.44 Quite High
Inflammatory response 8 72.80 Quite High
Inflammatory mediators 10 59.04 Quite High
corticosteroid 2 55.92 Quite High
Inflammatory stimuli 2 31.44 Quite Low
agonist 3 21.76 Low Low
Disease Link Frequency Relevance Heat
Adhesions 11 99.24 Very High Very High Very High
Fibrosis 7 97.16 Very High Very High Very High
Lymphedema 38 96.66 Very High Very High Very High
Occupational Lung Diseases 3 96.04 Very High Very High Very High
Pneumonia 6 92.68 High High
INFLAMMATION 124 87.84 High High
Infection 27 84.80 Quite High
Interstitial Lung Diseases 1 80.80 Quite High
Disease 11 80.76 Quite High
Necrosis 3 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subcutaneous tissue macrophages express the transcription factor tonicity enhancer binding protein in response to Na-mediated interstitial osmotic stress and thereby secrete vascular endothelial growth factor C, which stimulates lymphatic formation and endothelial nitric oxide synthase expression, suggesting that the immune system is a regulator of volume and blood pressure homeostasis.
Localization (secrete) of vascular endothelial growth factor C in blood
1) Confidence 0.78 Published 2010 Journal Curr. Opin. Nephrol. Hypertens. Section Body Doc Link 20571401 Disease Relevance 0 Pain Relevance 0
The development of lymphoedema may be attributed to the high interstitial protein concentration with increased osmotic pressure that causes retention of fluid in the connective tissue [15], and to release of growth factors, in particular vascular endothelial growth factor and basic fibroblast growth factor, that may bring about subcutaneous fibrosis and hyperkeratosis [15,16].


Localization (release) of vascular endothelial growth factor in connective tissue associated with fibrosis and lymphedema
2) Confidence 0.30 Published 2008 Journal AIDS Res Ther Section Body Doc Link PMC2275292 Disease Relevance 0.87 Pain Relevance 0.12
In our laboratory, we more recently found that bronchial ASM cells are capable of expressing and releasing vascular endothelial growth factor, an angiogenic peptide, following stimulation with TNF-?
Localization (releasing) of vascular endothelial growth factor
3) Confidence 0.25 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.76 Pain Relevance 0.20
and IL-6, and Ureaplasma-exposed macrophages release vascular endothelial growth factor and intracellular adhesion molecule-1.
Localization (release) of vascular endothelial growth factor in macrophages associated with adhesions
4) Confidence 0.07 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3021732 Disease Relevance 1.16 Pain Relevance 0.19

General Comments

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