INT169061

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 26
Disease Relevance 9.39
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pnp) extracellular region (Pnp) transferase activity, transferring glycosyl groups (Pnp)
cytoskeleton (Pnp) nucleus (Pnp) intracellular (Pnp)
Anatomy Link Frequency
poly 2
B cells 2
Pnp (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 9 80.64 Quite High
Potency 2 70.84 Quite High
ketamine 22 64.80 Quite High
imagery 8 52.40 Quite High
anesthesia 53 38.04 Quite Low
agonist 80 22.72 Low Low
cytokine 43 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
Buprenorphine 16 5.00 Very Low Very Low Very Low
Pain management 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 611 100.00 Very High Very High Very High
Neuropathy 6 100.00 Very High Very High Very High
Pox Virus Infection 84 99.86 Very High Very High Very High
Vesicular Stomatitis 20 99.56 Very High Very High Very High
Diabetes Mellitus 3 98.68 Very High Very High Very High
Infection 241 98.48 Very High Very High Very High
Cytomegalovirus Infection 11 97.96 Very High Very High Very High
Immunization 490 97.76 Very High Very High Very High
Sprains And Strains 272 94.56 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with type 2, symptoms of PNP can precede formal diagnosis of diabetes!
Gene_expression (symptoms) of PNP associated with neuropathy and diabetes mellitus
1) Confidence 0.66 Published 2010 Journal Praxis (Bern 1994) Section Abstract Doc Link 20571999 Disease Relevance 0.75 Pain Relevance 0.08
Plasmid DNA without an insert is often used as a control; although we used it initially, we later prepared a construct expressing the NP gene of influenza B/AA as a specificity control.
Gene_expression (expressing) of NP gene associated with influenza virus infection
2) Confidence 0.33 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2732511 Disease Relevance 0.53 Pain Relevance 0
The plasmid B/NP expresses the full-length NP gene from B/Ann Arbor/1/86 (B/AA), derived from a baculovirus vector generated by Rota et al. (34) and subcloned into VR1012.
Gene_expression (expresses) of NP gene
3) Confidence 0.29 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2732511 Disease Relevance 0.42 Pain Relevance 0
Thymidine kinase-negative (TK-) recombinant vaccinia virus expressing influenza A/PR/8/34 NP gene (NP-Vac) was provided by Dr.
Gene_expression (expressing) of NP associated with pox virus infection and influenza virus infection
4) Confidence 0.11 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 0.89 Pain Relevance 0.03
Protective effects of NP-specific CD8+
Gene_expression (effects) of NP
5) Confidence 0.11 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 1.35 Pain Relevance 0
Thymidine kinase-negative (TK-) recombinant vaccinia virus expressing influenza A/PR/8/34 NP gene (NP-Vac) was provided by Dr.
Gene_expression (expressing) of NP associated with pox virus infection and influenza virus infection
6) Confidence 0.10 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 0.89 Pain Relevance 0.03
Three separate replication-defective rAd serotype 5 vectors expressing HA (KAN-1), NP (KAN-1), and M2 (KAN-1) genes were produced as previously described [23].
Gene_expression (expressing) of NP
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.15 Pain Relevance 0
When HA and NP were present, significant humoral responses were stimulated against these proteins.
Gene_expression (present) of NP
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.60 Pain Relevance 0
Three separate replication-defective rAd serotype 5 vectors expressing HA (KAN-1), NP (KAN-1), and M2 (KAN-1) genes were produced as previously described [23].
Gene_expression (produced) of NP
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.15 Pain Relevance 0
For both NP and NP+M2 immunized groups, significant anti-NP humoral responses were observed after the rAd boost (p<0.0001) (Figure 4B, middle panel) compared to controls.
Gene_expression (groups) of NP
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.28 Pain Relevance 0
For both NP and NP+M2 immunized groups, significant anti-NP humoral responses were observed after the rAd boost (p<0.0001) (Figure 4B, middle panel) compared to controls.
Gene_expression (groups) of NP
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.28 Pain Relevance 0
Lalor et al. showed NP+M2 to be protective in mice, but only when formulated with Vaxfectin and in a vaccine dose 6.6 times greater than that used in this study.
Gene_expression (protective) of NP
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.40 Pain Relevance 0
For both NP and NP+M2 immunized groups, significant anti-NP humoral responses were observed after the rAd boost (p<0.0001) (Figure 4B, middle panel) compared to controls.
Gene_expression (groups) of NP
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.23 Pain Relevance 0
4); NP alone (n?
Gene_expression (alone) of NP
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.46 Pain Relevance 0
Plasmids encoding HA (A/Thailand/1(KAN-1)/2004, GenBank AY555150), NP (A/Thailand/1(KAN-1)/2004, GenBank AAV35112 and A/PR/8/34, GenBank AAM75159), and M2 (A/Thailand/1(KAN-1)/2004, GenBank AAV35111) were synthesized using human-preferred codons and constructed in a CMV/R backbone by GeneArt (Regensburg, Germany) as previously described [22].
Gene_expression (synthesized) of NP associated with cytomegalovirus infection
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.24 Pain Relevance 0
At week 9, the ferrets were immunized intramuscularly with 1010 particles of recombinant adenoviruses expressing HA, NP, M2, or in different combinations similar to their DNA immunization combinations.
Gene_expression (expressing) of NP associated with immunization
16) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.34 Pain Relevance 0
Western blot analysis confirmed the expression of HA protein of A/Thailand/1/KAN-1/2004 (Figure 1A, lane 2), NP protein of A/PR/8/34 (Figure 1A, lane 3) and A/Thailand/1/KAN-1/2004 (Figure 1A, lane 4), and M2 protein of A/Thailand/1/KAN-1/2004 (Figure 1A, lane 6) in 293T cells transfected by eukaryotic plasmid expression vectors.
Gene_expression (expression) of NP
17) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.10 Pain Relevance 0
The NP-specific mAb S43-10 (Reth et al., 1978) was used as a positive control for a high-affinity NP-specific IgG2c antibody with an affinities of Kd = 2.4 × 10?
Gene_expression (antibody) of NP-specific
18) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.05 Pain Relevance 0
The NP-specific mAb S43-10 (Reth et al., 1978) was used as a positive control for a high-affinity NP-specific IgG2c antibody with an affinities of Kd = 2.4 × 10?
Gene_expression (mAb) of NP-specific
19) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0 Pain Relevance 0
NP-Ficoll alone elicited Ig?
Gene_expression (elicited) of NP-Ficoll
20) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.07 Pain Relevance 0

General Comments

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