INT169072

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Context Info
Confidence 0.60
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 6.23
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h4) DNA binding (Nr1h4)
Anatomy Link Frequency
vasculature 1
spleen 1
thymus 1
heart 1
gut 1
Nr1h4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 169 100.00 Very High Very High Very High
antagonist 38 99.92 Very High Very High Very High
Bile 151 99.20 Very High Very High Very High
Paracetamol 6 97.36 Very High Very High Very High
anesthesia 24 89.00 High High
Inflammation 103 48.60 Quite Low
aspirin 30 5.00 Very Low Very Low Very Low
Angina 18 5.00 Very Low Very Low Very Low
tolerance 18 5.00 Very Low Very Low Very Low
Crohn's disease 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 16 99.88 Very High Very High Very High
Toxicity 16 98.08 Very High Very High Very High
Disorder Of Lipid Metabolism 1808 93.24 High High
Cardiovascular Disease 44 90.72 High High
Hyperlipidemia 12 88.00 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 85.08 High High
Coronary Heart Disease 420 81.40 Quite High
Dyslipidemia /

Combined Dyslipidemia

54 81.08 Quite High
Hepatotoxicity 6 69.04 Quite High
Targeted Disruption 58 63.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological activation of FXR induces the expression of several genes involved in phase II and phase III xenobiotic metabolism in wild-type, but not Fxr(-/-) mice.
Gene_expression (expression) of Fxr
1) Confidence 0.60 Published 2010 Journal Mol. Endocrinol. Section Abstract Doc Link 20573685 Disease Relevance 0.30 Pain Relevance 0.47
The NR farnesoid-X receptor, FXR was also 1.3-fold lower expressed in the SPF compared to GF mice.
Gene_expression (expressed) of farnesoid-X receptor
2) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
Interestingly, while the NR FXR was more highly expressed in the GF, compared to SPF mice, no significant difference in expression of PXR was detected indicating that the xenobiotic NRs involved may be differentially regulated by the gut flora.
Gene_expression (expressed) of FXR in gut
3) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.15
The NR farnesoid-X receptor, FXR was also 1.3-fold lower expressed in the SPF compared to GF mice.
Gene_expression (expressed) of FXR
4) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0
Cafestol, presented in unfiltered brewed coffee and the most potent cholesterol-elevating compound known in the human diet was recently found to be an agonist of both SXR and farnesoid X receptor (FXR) [Ricketts et al., 2007].
Gene_expression (agonist) of FXR associated with rickets and agonist
5) Confidence 0.23 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.70 Pain Relevance 0.08
Cafestol, presented in unfiltered brewed coffee and the most potent cholesterol-elevating compound known in the human diet was recently found to be an agonist of both SXR and farnesoid X receptor (FXR) [Ricketts et al., 2007].
Gene_expression (agonist) of farnesoid X receptor associated with rickets and agonist
6) Confidence 0.23 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.70 Pain Relevance 0.08
agonists, CETP inhibitors, D-4F and other apo A agonists, Cordaptive¬ô, and farnesoid X receptor (FXR) antagonists.
Gene_expression (agonists) of FXR associated with antagonist and agonist
7) Confidence 0.22 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.23 Pain Relevance 0.20
FXR is expressed in a wide variety of tissues, including the heart, kidney, thymus, and spleen, and vasculature.
Gene_expression (expressed) of FXR in kidney
8) Confidence 0.19 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.64 Pain Relevance 0.24
FXR is expressed in a wide variety of tissues, including the heart, kidney, thymus, and spleen, and vasculature.
Gene_expression (expressed) of FXR in spleen
9) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.64 Pain Relevance 0.24
FXR is expressed in a wide variety of tissues, including the heart, kidney, thymus, and spleen, and vasculature.
Gene_expression (expressed) of FXR in vasculature
10) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.64 Pain Relevance 0.24
FXR is expressed in a wide variety of tissues, including the heart, kidney, thymus, and spleen, and vasculature.
Gene_expression (expressed) of FXR in heart
11) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.64 Pain Relevance 0.24
FXR is expressed in a wide variety of tissues, including the heart, kidney, thymus, and spleen, and vasculature.
Gene_expression (expressed) of FXR in thymus
12) Confidence 0.07 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.64 Pain Relevance 0.24

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