INT169073

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.44
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1h4) DNA binding (Nr1h4)
Anatomy Link Frequency
bile 4
liver 2
Nr1h4 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 157 99.88 Very High Very High Very High
Paracetamol 12 98.84 Very High Very High Very High
antagonist 29 89.28 High High
agonist 79 83.88 Quite High
Inflammation 75 53.16 Quite High
Crohn's disease 20 30.76 Quite Low
antiepileptic Drug 3 6.72 Low Low
anesthesia 16 5.00 Very Low Very Low Very Low
aspirin 10 5.00 Very Low Very Low Very Low
antidepressant 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 18 99.48 Very High Very High Very High
Disorder Of Lipid Metabolism 612 98.08 Very High Very High Very High
Targeted Disruption 59 87.56 High High
Coronary Heart Disease 140 72.00 Quite High
Hepatotoxicity 10 64.68 Quite High
Atherosclerosis 112 61.00 Quite High
INFLAMMATION 60 53.16 Quite High
Disease 42 30.76 Quite Low
Diabetes Mellitus 35 29.96 Quite Low
Obesity 8 29.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological activation of FXR induces the expression of several genes involved in phase II and phase III xenobiotic metabolism in wild-type, but not Fxr(-/-) mice.
Positive_regulation (activation) of FXR
1) Confidence 0.47 Published 2010 Journal Mol. Endocrinol. Section Abstract Doc Link 20573685 Disease Relevance 0.23 Pain Relevance 0.40
Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.
Positive_regulation (Activation) of farnesoid X receptor associated with toxicity and paracetamol
2) Confidence 0.47 Published 2010 Journal Mol. Endocrinol. Section Title Doc Link 20573685 Disease Relevance 0.31 Pain Relevance 0.53
They form a NR network regulating a number of essential liver functions jointly with the bile acid activated Farnesoid X receptor (FXR) and the liver X receptor (LXR) [13].
Positive_regulation (activated) of Farnesoid X receptor in liver associated with bile
3) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.15
They form a NR network regulating a number of essential liver functions jointly with the bile acid activated Farnesoid X receptor (FXR) and the liver X receptor (LXR) [13].
Positive_regulation (activated) of FXR in liver associated with bile
4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.15
Bile acids activate FXR, which downregulates synthesis of bile acids and also leads to the transcriptional activation of SXR, thereby promoting bile acid metabolism.


Positive_regulation (activate) of FXR in bile associated with bile
5) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.19 Pain Relevance 0.27
Bile acid activated FXR represses the expression of CYP7A1 and CYP2B, enzymes involved in bile acid synthesis, through an indirect mechanism.
Positive_regulation (activated) of FXR in bile associated with bile
6) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.22
Bile acids activate FXR and induce the expression of small heterodimer partner (SHP), which binds to and inhibits the activity of liver receptor homolog-1 (LRH-1), which normally activates CYP7A1.
Positive_regulation (activate) of FXR in Bile associated with bile
7) Confidence 0.24 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.13 Pain Relevance 0.23
The role of FXR in HDL metabolism is unclear, however, the apoA-I and hepatic lipase expression are both inhibited by activated FXR.
Positive_regulation (activated) of FXR associated with disorder of lipid metabolism
8) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.76 Pain Relevance 0.23
One of the most important functions of FXR activation is to inhibit cholesterol 7-alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.
Positive_regulation (activation) of FXR in bile associated with bile
9) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.68 Pain Relevance 0.27

General Comments

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