INT169088

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.32
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIA3) plasma membrane (GRIA3) protein complex (GRIA3)
Anatomy Link Frequency
neuronal 2
neuron 2
GRIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 53 100.00 Very High Very High Very High
Migraine 187 99.24 Very High Very High Very High
Dopamine 10 93.28 High High
Neuropeptide 5 91.92 High High
agonist 15 91.60 High High
Glutamate 85 90.16 High High
depression 24 90.00 High High
Neurotransmitter 43 89.76 High High
antagonist 44 89.04 High High
Action potential 10 80.00 Quite High
Disease Link Frequency Relevance Heat
Headache 183 99.24 Very High Very High Very High
Depression 24 90.00 High High
Neurodegenerative Disease 45 82.32 Quite High
Epilepsy 25 78.20 Quite High
Stress 4 70.88 Quite High
Neurological Disease 10 36.08 Quite Low
Migraine With Aura 12 24.40 Low Low
Obesity 15 16.28 Low Low
Aging 5 14.56 Low Low
Osteoporosis 10 13.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the -1952T>C polymorphism may affect the GRIA3 promoter binding affinity with nuclear proteins and in turn the GRIA3 expression, which consequently modulates the individual's susceptibility to migraine.
Gene_expression (expression) of GRIA3 associated with migraine
1) Confidence 0.76 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.39 Pain Relevance 0.31
These variants modify binding sites for transcription factors altering the expression of GRIA1 and GRIA3 genes in different conditions.
Gene_expression (expression) of GRIA3
2) Confidence 0.75 Published 2010 Journal BMC Med. Genet. Section Body Doc Link 20579352 Disease Relevance 0.07 Pain Relevance 0
Primers used for GRIA3 SNP were:
Gene_expression (used) of GRIA3
3) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0 Pain Relevance 0
Further remarkable in our cohort is that GRIA1 and GRIA3 variants are associated to migraine in female but not in male subjects.
Gene_expression (variants) of GRIA3 associated with migraine
4) Confidence 0.66 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.28 Pain Relevance 0.31
These variants modify binding sites for transcription factors altering the expression of GRIA1 and GRIA3 genes in different conditions.


Gene_expression (expression) of GRIA3
5) Confidence 0.59 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2909201 Disease Relevance 0.37 Pain Relevance 0.34
As show in figure 4, using quantitative real-time PCR, we confirmed the increased expression of EphA4, AMPA3, NEGR1, NEF3 and PENK by differentiated MSC ten days after neurogenic induction.
Gene_expression (expression) of AMPA3
6) Confidence 0.41 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.06 Pain Relevance 0.07
In our present study, microarray analysis and real-time PCR, realized both on BM-MSC and neuron-like cells, have demonstrated an increased expression of ionotropic glutamate receptor AMPA3, also called GRIA3 or GluR3.
Gene_expression (expression) of GRIA3 in neuron associated with glutamate receptor
7) Confidence 0.41 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0 Pain Relevance 0.57
Using real time RT-PCR, we confirmed the expression of selected neuronal genes: NEGR1, GRIA3 (AMPA3), NEF3, PENK and Epha4.
Gene_expression (expression) of AMPA3 in neuronal
8) Confidence 0.41 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0.25
Using real time RT-PCR, we confirmed the expression of selected neuronal genes: NEGR1, GRIA3 (AMPA3), NEF3, PENK and Epha4.
Gene_expression (expression) of GRIA3 in neuronal
9) Confidence 0.41 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0.25
In our present study, microarray analysis and real-time PCR, realized both on BM-MSC and neuron-like cells, have demonstrated an increased expression of ionotropic glutamate receptor AMPA3, also called GRIA3 or GluR3.
Gene_expression (expression) of AMPA3 in neuron associated with glutamate receptor
10) Confidence 0.36 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox