INT169090

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIA3) plasma membrane (GRIA3) protein complex (GRIA3)
GRIA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 49 97.36 Very High Very High Very High
Glutamate receptor 7 14.48 Low Low
Glutamate 16 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
trigeminal ganglion 1 5.00 Very Low Very Low Very Low
central sensitization 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 48 97.36 Very High Very High Very High
Stress 1 74.12 Quite High
Migraine With Aura 3 24.40 Low Low
Depression 6 5.00 Very Low Very Low Very Low
Epilepsy 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the -1952T>C polymorphism may affect the GRIA3 promoter binding affinity with nuclear proteins and in turn the GRIA3 expression, which consequently modulates the individual's susceptibility to migraine.
Spec (may) Regulation (affect) of Gene_expression (expression) of GRIA3 associated with migraine
1) Confidence 0.61 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.39 Pain Relevance 0.32
These variants modify binding sites for transcription factors altering the expression of GRIA1 and GRIA3 genes in different conditions.
Regulation (altering) of Gene_expression (expression) of GRIA3
2) Confidence 0.60 Published 2010 Journal BMC Med. Genet. Section Body Doc Link 20579352 Disease Relevance 0.07 Pain Relevance 0

General Comments

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