INT16917

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Context Info
Confidence 0.12
First Reported 1991
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.17
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL36RN) extracellular region (IL36RN)
Anatomy Link Frequency
monocytes 2
neurons 2
astrocytes 2
PGE2 2
IL36RN (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 12 100.00 Very High Very High Very High
antagonist 17 99.92 Very High Very High Very High
adenocard 16 99.68 Very High Very High Very High
Inflammatory response 1 99.34 Very High Very High Very High
Arthritis 10 97.92 Very High Very High Very High
Pain 3 97.84 Very High Very High Very High
Inflammation 4 97.08 Very High Very High Very High
pulpitis 2 85.04 High High
dexamethasone 3 73.08 Quite High
cINOD 4 61.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 9 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Stress 8 99.74 Very High Very High Very High
Syndrome 162 99.28 Very High Very High Very High
INFLAMMATION 6 99.16 Very High Very High Very High
Arthritis 4 98.96 Very High Very High Very High
Experimental Arthritis 8 97.92 Very High Very High Very High
Pain 3 97.84 Very High Very High Very High
Pressure And Volume Under Development 6 97.60 Very High Very High Very High
Atherosclerosis 2 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of interleukin-1 (IL)-1, tumor necrosis factor-alpha (TNF-alpha), IL-6, and prostaglandin E2 (PGE2) have been detected in inflamed pulp tissue.
Positive_regulation (Increased) of Gene_expression (levels) of interleukin-1 in PGE2 associated with necrosis and cancer
1) Confidence 0.12 Published 2002 Journal J Endod Section Abstract Doc Link 12017180 Disease Relevance 0.28 Pain Relevance 0.12
While the ARE-specific inducer tBHQ did not modulate the basal expression of MGST1-L1, it was found to act as an antagonist of interleukin-1 beta-stimulated MGST1-L1 overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of interleukin-1 associated with antagonist
2) Confidence 0.08 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12818365 Disease Relevance 0.33 Pain Relevance 0.11
It also inhibited production of interleukin-1, tumor necrosis factor-alpha, and PGE(2) and increased cyclic adenosine monophosphate levels in rats with AA.
Positive_regulation (increased) of Gene_expression (production) of interleukin-1 associated with necrosis, adenocard, cancer and arthritis
3) Confidence 0.06 Published 2007 Journal Adv Ther Section Abstract Doc Link 17660179 Disease Relevance 1.69 Pain Relevance 0.74
A major initiator of an inflammatory response is oxidative stress through the production and activation of proinflammatory cytokines, especially interleukin-1, interleukin-6, C-reactive protein, and tumor necrosis factor-a.
Positive_regulation (activation) of Gene_expression (production) of interleukin-1 associated with stress, necrosis, inflammatory response, cancer and cytokine
4) Confidence 0.04 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 1.00 Pain Relevance 0.17
The mechanism of action is thought to be that aminobisphosphonates transiently stimulate the production of proinflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha.
Positive_regulation (stimulate) of Gene_expression (production) of interleukin-1 associated with necrosis, cancer and cytokine
5) Confidence 0.03 Published 2006 Journal J Clin Rheumatol Section Abstract Doc Link 16755241 Disease Relevance 0.67 Pain Relevance 0.20
The expression of cell surface proteins on monocytes, including HLA-DR, HLA-DQ, beta 2-microglobulin, and the Fc receptor, and serum interleukin-1 activity also were not significantly increased by the administration of TNF.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of interleukin-1 in monocytes
6) Confidence 0.02 Published 1991 Journal Cancer Res. Section Abstract Doc Link 1998956 Disease Relevance 0.69 Pain Relevance 0.16
Ionic mechanism of the outward current induced by extracellular ejection of interleukin-1 onto identified neurons of Aplysia.
Positive_regulation (induced) of Gene_expression (ejection) of interleukin-1 in neurons
7) Confidence 0.01 Published 1991 Journal Brain Res. Section Title Doc Link 1860049 Disease Relevance 0 Pain Relevance 0.06
In addition, there is increased S100 and interleukin-1 expression in astrocytes in DS brain cortex [59], [60].
Positive_regulation (increased) of Gene_expression (expression) of interleukin-1 in astrocytes associated with syndrome
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.50 Pain Relevance 0

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