INT169173

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.49
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nucleus accumbens 1
elbow joint 1
cortex 1
ocd (Mus musculus)
Pain Link Frequency Relevance Heat
deep brain stimulation 24 100.00 Very High Very High Very High
Nucleus accumbens 12 100.00 Very High Very High Very High
Thalamus 24 97.52 Very High Very High Very High
sNRI 4 89.52 High High
sSRI 139 89.24 High High
Serotonin 51 71.76 Quite High
cingulotomy 4 65.20 Quite High
Glutamate 68 61.84 Quite High
Lasting pain 2 42.84 Quite Low
antidepressant 1 40.00 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 855 100.00 Very High Very High Very High
Autism 4 93.84 High High
Obsessive-compulsive Disorder 50 73.20 Quite High
Arthralgia 4 60.32 Quite High
Attention Deficit Hyperactivity Disorder 36 58.88 Quite High
Osteochondritis Dissecans 8 58.52 Quite High
Cognitive Disorder 36 43.12 Quite Low
Pain 2 42.84 Quite Low
Depression 6 37.40 Quite Low
Disease 47 21.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional studies have shown effectiveness of DBS in the nucleus accumbens (NAc) region in OCD [61, 62], and an investigation into the detailed mechanism of NAc DBS in rats found that activity in orbitofrontal cortex was reduced through a complex form of recurrent inhibition involving antidromic activation of cortico-striatal axon collaterals [63]

OCD Precipitated by Basal Ganglia Disruptions

Gene_expression (effectiveness) of OCD in nucleus accumbens associated with nucleus accumbens, deep brain stimulation and anxiety disorder
1) Confidence 0.50 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.85 Pain Relevance 0.49
No clear association between SAPAP3 variants and OCD was reported, although it is noteworthy that GDs without OCD were uncommon in this study.
Gene_expression (variants) of OCD associated with anxiety disorder
2) Confidence 0.50 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.83 Pain Relevance 0.03
This study found no evidence for association for three SNPs in GRIK2 and one SNP in GRIK3, however, a separate transmission disequilibrium test revealed a significant under-transmission of the I867 allele of SNP rs2238076 in OCD.
Gene_expression (transmission) of OCD associated with anxiety disorder
3) Confidence 0.50 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.61 Pain Relevance 0
Additional studies have shown effectiveness of DBS in the nucleus accumbens (NAc) region in OCD [61, 62], and an investigation into the detailed mechanism of NAc DBS in rats found that activity in orbitofrontal cortex was reduced through a complex form of recurrent inhibition involving antidromic activation of cortico-striatal axon collaterals [63]

OCD Precipitated by Basal Ganglia Disruptions

Gene_expression ([61) of OCD in cortex associated with nucleus accumbens, deep brain stimulation and anxiety disorder
4) Confidence 0.50 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.83 Pain Relevance 0.49
Again, to validate the predicted association between milnacipran and OCD, we inquired the literature from May 1, 2007 until present for studies that report on a functional relationship between milnacipran and OCD.
Gene_expression (milnacipran) of OCD associated with anxiety disorder
5) Confidence 0.09 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 1.15 Pain Relevance 0.27
The areas under the ROC curves were significantly larger for the Cr15L-CdMO and CC views than for the ML, flexed ML, and Di35M-PrLO views for the detection of OCD.
Gene_expression (detection) of OCD
6) Confidence 0.09 Published 2010 Journal Am. J. Vet. Res. Section Body Doc Link 20594080 Disease Relevance 0.05 Pain Relevance 0
At 95% specificity, median sensitivities to detect OCD were 57% for Cr15L-CdMO, 56% for CC, 10% for flexed ML, 7% for ML, and 4% for Di35M-PrLO views.
Gene_expression (detect) of OCD
7) Confidence 0.07 Published 2010 Journal Am. J. Vet. Res. Section Body Doc Link 20594080 Disease Relevance 0.18 Pain Relevance 0
Only the Cr15L-CdMO and CC views allowed accurate detection of OCD.
Gene_expression (detection) of OCD
8) Confidence 0.07 Published 2010 Journal Am. J. Vet. Res. Section Body Doc Link 20594080 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS AND CLINICAL RELEVANCE: In dogs with signs of elbow joint pain, the Cr15L-CdMO view is excellent and the CC view was good for detection of OCD.


Gene_expression (detection) of OCD in elbow joint
9) Confidence 0.07 Published 2010 Journal Am. J. Vet. Res. Section Body Doc Link 20594080 Disease Relevance 0 Pain Relevance 0

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