INT169180

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2011
Negated 15
Speculated 7
Reported most in Body
Documents 204
Total Number 211
Disease Relevance 119.10
Pain Relevance 29.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) mRNA processing (SNRNP70) RNA binding (SNRNP70)
nucleus (SNRNP70)
Anatomy Link Frequency
skin 8
posterior 4
joint 4
knee 4
plasma 2
SNRNP70 (Homo sapiens)
SNRNP70 - T1805G (1) SNRNP70 - D19H (1)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1317 100.00 Very High Very High Very High
spinal inflammation 279 100.00 Very High Very High Very High
Osteoarthritis 632 99.78 Very High Very High Very High
Pain 1029 99.76 Very High Very High Very High
Arthritis 778 99.76 Very High Very High Very High
Morphine 175 99.76 Very High Very High Very High
Fibrositis 41 99.76 Very High Very High Very High
Crohn's disease 237 99.72 Very High Very High Very High
opioid receptor 37 99.72 Very High Very High Very High
addiction 118 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 2687 100.00 Very High Very High Very High
Rheumatoid Arthritis 1436 100.00 Very High Very High Very High
Coronary Artery Disease 1284 100.00 Very High Very High Very High
Asthma 348 100.00 Very High Very High Very High
Low Back Pain 310 100.00 Very High Very High Very High
Acute Coronary Syndrome 293 100.00 Very High Very High Very High
Mycobacterium Infection 258 100.00 Very High Very High Very High
Sleep Disorders 228 100.00 Very High Very High Very High
Diabetes Mellitus 1789 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 1054 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The KCNJ9 SNP (rs2494211) has been previously associated with type 2 diabetes in Pima Indians [21], and the T allele of the KCNJ10 SNP (rs1130183) showed a significant association with seizure resistance in the common forms of focal and generalized epilepsy patients, suggesting that this variation is related to general seizure susceptibility in humans [22].
SNP Binding (associated) of associated with convulsion, diabetes mellitus and generalized epilepsy
1) Confidence 0.47 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 1.45 Pain Relevance 0.43
Among these, the association of SNP rs324987 with ACPA-negative RA [(p?
SNP Binding (association) of associated with rheumatoid arthritis
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2825264 Disease Relevance 1.27 Pain Relevance 0.50
We also investigated SNP associations in candidate genes and regions reported to be associated with longevity identified from established databases including NCBI [14] using the search term "longevity" and the Science of Aging Knowledge Environment genes/intervention database [30] choosing genes potentially related to lifespan in humans.
SNP Binding (associations) of associated with aging and lifespan
3) Confidence 0.47 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1995604 Disease Relevance 0.97 Pain Relevance 0
For example, we previously reported the association of a TPH2 promoter SNP (-614T>A; rs11178997) with reduced transcriptional activity [23], whereas another allelic TPH2 promoter variant (-844G>T; rs4570625) was shown to associate with amygdala hyperexcitabilty in reaction to emotional stimuli [24], [25].
SNP Binding (association) of in amygdala associated with amygdala
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.54 Pain Relevance 0.05
By examining the strength of association of each SNP with each disease (p-value), we found a set of SNPs which are significantly associated with all 5 autoimmune diseases in our dataset (Table 1).
SNP Binding (associated) of associated with autoimmune disease and disease
5) Confidence 0.47 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 2.09 Pain Relevance 0.31
Among these, the association of the SNP rs10263447 remained significant after Bonferroni correction when a dominant model was tested on the entire sample [p?
SNP Binding (association) of
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825264 Disease Relevance 0.60 Pain Relevance 0.17
Following on from their analysis of genomic convergence Gregory et al. (2007) established significant association with the IL7R SNP rs6897932 (P = 2.9 × 10?
SNP Binding (association) of
7) Confidence 0.47 Published 2008 Journal Brain Section Body Doc Link PMC2639203 Disease Relevance 0.21 Pain Relevance 0.10
In the final analysis (employing a total of 12 360 individuals), association with rs6897932 (the IL7R associated SNP) was confirmed and significant association was also established with rs12722489 (P = 3.0 × 10?
SNP Binding (association) of
8) Confidence 0.47 Published 2008 Journal Brain Section Body Doc Link PMC2639203 Disease Relevance 0.43 Pain Relevance 0.17
Furthermore, we did not find any evaluated association of the same SLC2A9 SNP with hypertension under an additive model in 5,249 hypertensive cases and 6,648 normotensive controls drawn from all the studies.
SNP Neg (not) Binding (association) of associated with hypertension
9) Confidence 0.47 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2561076 Disease Relevance 0.28 Pain Relevance 0
This suggests that the allelic association of the two ESR2 SNPs in sample 1 was spurious.
SNP Binding (association) of
10) Confidence 0.47 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.02 Pain Relevance 0
As shown in Table 3, all three SNPs are highly associated with every single one of these clinical subtypes.
SNP Binding (associated) of
11) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.36 Pain Relevance 0
For ESR2 SNPs rs1152582, rs1271572 and rs1269056, allelic associations with obesity were observed in women, nominal P value 0.03–0.05, but not in joint analysis of women and men, Table 4.
SNP Binding (associations) of in joint associated with obesity
12) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.91 Pain Relevance 0
Two ESR2 SNPs, rs7154455 and rs3020450, displayed allelic association with obesity in the joint analysis of women and men, nominal P value 0.0003–0.01, Table 4.
SNP Binding (association) of in joint associated with obesity
13) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.67 Pain Relevance 0
Relation of ESR1 SNPs and mRNA levels to adipocyte lipolysis and lipogenesis phenotypes
SNP Binding (Relation) of in adipocyte
14) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.83 Pain Relevance 0.10
The two highly associated SNPs of rs1048661 (R141L; basic arginine replaced by neutral and hydrophobic leucine) and rs3825942 (G153D; neutral and polar glycine replace by acidic aspartic acid) are part of the coding region of the LOXL1 protein, and these two amino acids are highly conserved during evolution.
SNP Binding (associated) of
15) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.43 Pain Relevance 0
Two ESR2 SNPs, rs7154455 and rs3020450, displayed allelic association with obesity in the joint analysis of women and men, nominal P value 0.0003–0.01, Table 4.
SNP Binding (Two) of in joint associated with obesity
16) Confidence 0.36 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.60 Pain Relevance 0
In contrast, the current study does not corroborate the previous association between SNP LTC4S-rs730012 (also known as -444A/C) and allergic rhinitis [28].
SNP Neg (not) Binding (association) of associated with rhinitis
17) Confidence 0.36 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2292155 Disease Relevance 0.64 Pain Relevance 0.03
In some cases a complete set of tagged SNPs (tagSNPs) for a given candidate gene was not possible because of these competing criteria.
SNP Binding (set) of
18) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920916 Disease Relevance 0.12 Pain Relevance 0
In addition to APL, family-based association of FAM5C SNPs was performed using the Pedigree Disequilibrium Test (PDT) [42,43].
SNP Binding (association) of
19) Confidence 0.36 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.12 Pain Relevance 0
In particular, the associations between SNP rs324987 and ACPA-negative RA (p?
SNP Binding (associations) of associated with rheumatoid arthritis
20) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825264 Disease Relevance 0.82 Pain Relevance 0.36

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