INT169189

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Context Info
Confidence 0.76
First Reported 2010
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 1
Total Number 6
Disease Relevance 7.31
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam10) Golgi apparatus (Adam10) nucleus (Adam10)
cytoplasm (Adam10)
Adam10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 18 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 18 100.00 Very High Very High Very High
Metastasis 12 100.00 Very High Very High Very High
Pancreatic Cancer 48 99.88 Very High Very High Very High
Pancreatitis 18 98.88 Very High Very High Very High
Wound Healing 6 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADAM10 expression in normal pancreatic (NP), chronic pancreatitis (CP), PDAC tissues, as well as PDAC cell lines was determined.
Spec (determined) Gene_expression (expression) of ADAM10 associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.76 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20596609 Disease Relevance 1.22 Pain Relevance 0.27
Western blotting and immunohistochemistry revealed stronger ADAM10 expression in PDAC than in NP.
Gene_expression (expression) of ADAM10 associated with pancreatic cancer
2) Confidence 0.67 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20596609 Disease Relevance 1.28 Pain Relevance 0.26
The protease ADAM10 influences progression and metastasis of cancer cells and is overexpressed in various malignancies.
Gene_expression (overexpressed) of ADAM10 associated with cancer and metastasis
3) Confidence 0.67 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20596609 Disease Relevance 1.02 Pain Relevance 0.22
To evaluate whether rhADAM10 or ADAM10 silencing influences cancer cell viability, MTT assay was used.
Spec (whether) Gene_expression (silencing) of rhADAM10 associated with cancer
4) Confidence 0.58 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20596609 Disease Relevance 1.32 Pain Relevance 0.28
To evaluate whether rhADAM10 or ADAM10 silencing influences cancer cell viability, MTT assay was used.
Spec (whether) Gene_expression (silencing) of ADAM10 associated with cancer
5) Confidence 0.58 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20596609 Disease Relevance 1.31 Pain Relevance 0.28
Therefore, the aim of our study was to evaluate the expression and potential function of ADAM10 in the pathophysiology of pancreatic cancer (PDAC).
Gene_expression (expression) of ADAM10 associated with pancreatic cancer
6) Confidence 0.52 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20596609 Disease Relevance 1.16 Pain Relevance 0.25

General Comments

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