INT169194

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.23
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP7) nucleoplasm (CASP7) peptidase activity (CASP7)
aging (CASP7) cytoplasm (CASP7)
Anatomy Link Frequency
MCF-7 1
head 1
CASP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 81.92 Quite High
cINOD 3 79.76 Quite High
Chronic pancreatitis 1 29.68 Quite Low
Central nervous system 1 29.04 Quite Low
cOX1 1 25.00 Low Low
palliative 1 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
visual analogue scale 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 3 99.38 Very High Very High Very High
Breast Cancer 8 97.12 Very High Very High Very High
Pruritus 8 96.88 Very High Very High Very High
Apoptosis 15 96.36 Very High Very High Very High
Louse Infestation 18 91.84 High High
Pancreatic Cancer 31 91.56 High High
Cancer 20 72.96 Quite High
INFLAMMATION 1 67.56 Quite High
Neuroblastoma 2 52.80 Quite High
Colon Cancer 2 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Outcome measures were defined as cure (absence of vital head lice) after first application and before and after second applications, degree of itching, cosmetic acceptability, and clinical pathology.


Negative_regulation (absence) of lice in head associated with pruritus
1) Confidence 0.26 Published 2008 Journal BMC Infect Dis Section Abstract Doc Link PMC2553415 Disease Relevance 0.40 Pain Relevance 0
Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells.
Negative_regulation (suppress) of effector caspase-7 in MCF-7 associated with breast cancer and apoptosis
2) Confidence 0.08 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.99 Pain Relevance 0.26
It blocks common downstream elements of both the mitochondrial pathway and the death receptor pathway, by directly inhibiting terminal effector caspase-3, caspase-7, and caspase-9 activity[1,2].
Negative_regulation (inhibiting) of caspase-7 associated with death
3) Confidence 0.07 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.84 Pain Relevance 0

General Comments

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