INT169195

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.99 Pain Relevance 0.26

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1) intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)

Anatomy Link Frequency MCF-7 2 PARP1 (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 1 81.92 cINOD 3 80.48 cOX1 1 25.00

Disease Link Frequency Relevance Heat Breast Cancer 6 97.48 Apoptosis 4 96.36 Death 1 75.00 Cancer 2 72.96 INFLAMMATION 1 67.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells.

Negative_regulation (suppress) of Localization (cleavage) of PARP in MCF-7 associated with breast cancer and apoptosis

1) Confidence 0.27 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.99 Pain Relevance 0.26

General Comments

This test has worked.