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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
MCF-7 2
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 81.92 Quite High
cINOD 3 80.48 Quite High
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Breast Cancer 6 97.48 Very High Very High Very High
Apoptosis 4 96.36 Very High Very High Very High
Death 1 75.00 Quite High
Cancer 2 72.96 Quite High
INFLAMMATION 1 67.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells.
Negative_regulation (suppress) of Localization (cleavage) of PARP in MCF-7 associated with breast cancer and apoptosis
1) Confidence 0.27 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.99 Pain Relevance 0.26

General Comments

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