INT169218

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 8
Disease Relevance 2.80
Pain Relevance 5.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
neurons 7
EGFR (Homo sapiens)
Coc (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 128 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 24 99.12 Very High Very High Very High
Parkinson's Disease 8 76.48 Quite High
Apoptosis 16 65.28 Quite High
Death 16 37.76 Quite Low
Necrosis 8 25.00 Low Low
Attention Deficit Hyperactivity Disorder 8 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, Her followed by Coc (Her+Coc) and Her plus Coc (Her:Coc, 1:1).
Her Binding (incubated) of Coc in neurons associated with drug induced neurotoxicity and cocaine
1) Confidence 0.06 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.37 Pain Relevance 0.74
In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, Her followed by Coc (Her+Coc) and Her plus Coc (Her:Coc, 1:1).
Her Binding (incubated) of Coc in neurons associated with drug induced neurotoxicity and cocaine
2) Confidence 0.06 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.37 Pain Relevance 0.74
In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, Her followed by Coc (Her+Coc) and Her plus Coc (Her:Coc, 1:1).
Her Binding (incubated) of Coc in neurons associated with drug induced neurotoxicity and cocaine
3) Confidence 0.06 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.37 Pain Relevance 0.74
In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, Her followed by Coc (Her+Coc) and Her plus Coc (Her:Coc, 1:1).
Her Binding (incubated) of Coc in neurons associated with drug induced neurotoxicity and cocaine
4) Confidence 0.05 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.36 Pain Relevance 0.74
In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, Her followed by Coc (Her+Coc) and Her plus Coc (Her:Coc, 1:1).
Her Binding (incubated) of Coc in neurons associated with drug induced neurotoxicity and cocaine
5) Confidence 0.05 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.37 Pain Relevance 0.74
In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, Her followed by Coc (Her+Coc) and Her plus Coc (Her:Coc, 1:1).
Her Binding (incubated) of Coc in neurons associated with drug induced neurotoxicity and cocaine
6) Confidence 0.05 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.37 Pain Relevance 0.74
In this work, we evaluated whether combinations of Coc and Her affect the neurotoxicity of these drugs, using rat cortical neurons incubated with Coc, Her, Her followed by Coc (Her+Coc) and Her plus Coc (Her:Coc, 1:1).
Her Binding (incubated) of Coc in neurons associated with drug induced neurotoxicity and cocaine
7) Confidence 0.05 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.36 Pain Relevance 0.74
Recently, chemical interactions between heroin (Her) or its metabolite morphine (Mor) and cocaine (Coc) were described, resulting in the formation of strong adducts.
Her Binding (interactions) of Coc associated with cocaine and morphine
8) Confidence 0.05 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.22 Pain Relevance 0.67

General Comments

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