INT16923

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1991
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 25.01
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tnni3)
Anatomy Link Frequency
myocardium 2
coronary artery 2
myocardial cell 1
chest 1
heart 1
Tnni3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 69 99.90 Very High Very High Very High
Pain 3 99.04 Very High Very High Very High
depression 2 98.80 Very High Very High Very High
ischemia 35 98.52 Very High Very High Very High
cocaine 9 98.28 Very High Very High Very High
imagery 14 93.60 High High
Percutaneous transluminal coronary angioplasty 2 75.00 Quite High
iatrogenic 1 75.00 Quite High
agonist 3 71.48 Quite High
Central nervous system 8 59.04 Quite High
Disease Link Frequency Relevance Heat
Angina 22 99.90 Very High Very High Very High
Cv General 3 Under Development 48 99.82 Very High Very High Very High
Stress 49 99.76 Very High Very High Very High
Ventricular Remodeling 88 99.68 Very High Very High Very High
Injury 20 99.68 Very High Very High Very High
Amyloidosis 3 99.66 Very High Very High Very High
Thyroid Disease 2 99.56 Very High Very High Very High
Coronary Heart Disease 8 99.36 Very High Very High Very High
Myocardial Infarction 125 99.28 Very High Very High Very High
Shock 8 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 132 consecutive patients (89 male, 43 female) complete data sets consisting of case history (H; abnormal: typical angina), ECG (abnormal: ST-depression, T-inversion, atypical ST-elevation, LBBB), serum markers (TnI; abnormal: elevation of troponin I=0.5 ng/ml), ECHO (abnormal: WMA) and follow-up were available.
Positive_regulation (elevation) of TnI associated with angina, depression and congenital anomalies
1) Confidence 0.50 Published 2002 Journal Int. J. Cardiol. Section Abstract Doc Link 12127375 Disease Relevance 1.15 Pain Relevance 0.38
TFR (40 mg/kg) preconditioning significantly inhibited the increase of serum cTnI induced by I/R injury and increased the expression of iNOS both at mRNA and protein levels in rat myocardium.
Positive_regulation (increase) of cTnI in myocardium associated with injury
2) Confidence 0.49 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18418440 Disease Relevance 0.48 Pain Relevance 0.10
We report a series of children with clinical myocarditis presenting with chest pain and elevated cardiac troponin I mimicking coronary syndrome.
Positive_regulation (elevated) of cardiac troponin I in chest associated with angina, syndrome and coronary heart disease
3) Confidence 0.49 Published 2009 Journal J. Pediatr. Section Abstract Doc Link 19324224 Disease Relevance 0.45 Pain Relevance 0.15
Following cardiac surgery (ACVB) 6 to 48 hours after aortic unclamping 76 patients with TnI < 1 microgram/l had no perioperative myocardial infarction, while 14 patients with TnI concentrations > 1 microgram/l in 71.4% (n = 10) developed an acute infarction. - In patients in critical care units we observed only increased TnI concentrations in shock, especially in septic shock with multiple organ failures.
Positive_regulation (increased) of TnI associated with multiple organ failure, shock, infarction, sepsis and myocardial infarction
4) Confidence 0.48 Published 1996 Journal Med. Klin. (Munich) Section Abstract Doc Link 8767305 Disease Relevance 0.89 Pain Relevance 0.19
After coronary angioplasty and heparin treatment all patients had once more an elevation of TnT and TnI 8 and 27 hours after the invasive therapy.
Positive_regulation (elevation) of TnI
5) Confidence 0.48 Published 1996 Journal Med. Klin. (Munich) Section Abstract Doc Link 8767305 Disease Relevance 0.94 Pain Relevance 0.36
In stable angina the concentration of both Troponins were in normal range, in contrast in 33 to 41% of all patients with unstable angina TnT and TnI were increased, in 9 to 16% even if the ECG showed no alteration.
Positive_regulation (increased) of TnI associated with angina
6) Confidence 0.48 Published 1996 Journal Med. Klin. (Munich) Section Abstract Doc Link 8767305 Disease Relevance 1.04 Pain Relevance 0.41
There was a statistically significant increase in angina and coronary surgery with increasing levels of cardiac troponin I (Group B) (13 vs 5, p < 0.0001), multiple vessel disease (16 vs 18, p < 0.0008) and myocardial infarction (12% vs 0%, p < 0.03).
Positive_regulation (increasing) of cardiac troponin I
7) Confidence 0.37 Published 1999 Journal Rev Port Cardiol Section Body Doc Link 10608161 Disease Relevance 0.06 Pain Relevance 0
Addition of Isoprenaline to the electrically paced (5 Hz) heart caused marked elevations of the cMyBP-C and cTnI phosphorylation levels, but did not result in a further significant increase in MLC-2 phosphorylation.
Positive_regulation (elevations) of cTnI in heart
8) Confidence 0.36 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.03
TFR (40 mg/kg) preconditioning significantly inhibited the increase of serum cTnI induced by I/R injury and increased the expression of iNOS both at mRNA and protein levels in rat myocardium.
Positive_regulation (induced) of cTnI in myocardium associated with injury
9) Confidence 0.33 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18418440 Disease Relevance 0.48 Pain Relevance 0.10
One of these substantial reasons for these minor myocardial cell necrosis is beside the endothelial injury the activation of the platelets and the coagulation system. - During the therapy with hirudin increases of TnT and TnI was not observed.
Positive_regulation (increases) of TnI in myocardial cell associated with necrosis and injury
10) Confidence 0.32 Published 1996 Journal Med. Klin. (Munich) Section Abstract Doc Link 8767305 Disease Relevance 0.82 Pain Relevance 0.23
There were statistically significant increases in mortality with increasing levels of cardiac troponin I (P < 0.001).
Positive_regulation (increasing) of cardiac troponin I
11) Confidence 0.29 Published 1996 Journal N. Engl. J. Med. Section Body Doc Link 8857017 Disease Relevance 0.14 Pain Relevance 0
Each increase of 1 ng per milliliter in the cardiac troponin I level was associated with a significant increase (P = 0.03) in the risk ratio for death after adjustment for the base-line characteristics that were independently predictive of mortality (ST-segment depression and age > or = 65 years).
Positive_regulation (increase) of cardiac troponin I
12) Confidence 0.29 Published 1996 Journal N. Engl. J. Med. Section Body Doc Link 8857017 Disease Relevance 0.13 Pain Relevance 0
One patient of 18 patients (6%) in group C with negative stress test results had an elevated serum cardiac troponin I level after the stress test, but none of group A or group B patients had elevated troponin I levels.
Positive_regulation (elevated) of cardiac troponin I associated with stress
13) Confidence 0.27 Published 2002 Journal Heart Dis Section Abstract Doc Link 12147181 Disease Relevance 1.00 Pain Relevance 0.19
These data show that serum cardiac troponin I levels do not increase with stress test-induced myocardial ischemia.
Neg (not) Positive_regulation (increase) of cardiac troponin I associated with stress, coronary artery disease and ischemia
14) Confidence 0.27 Published 2002 Journal Heart Dis Section Abstract Doc Link 12147181 Disease Relevance 1.13 Pain Relevance 0.18
Overall, 30 patients (22%) had reversible perfusion defects on stress images, and none (0%) had increased serum cardiac troponin I levels.
Positive_regulation (increased) of cardiac troponin I associated with stress
15) Confidence 0.27 Published 2002 Journal Heart Dis Section Abstract Doc Link 12147181 Disease Relevance 1.02 Pain Relevance 0.19
Does the serum cardiac troponin I level increase with stress test-induced myocardial ischemia?
Positive_regulation (increase) of cardiac troponin I associated with stress, coronary artery disease and ischemia
16) Confidence 0.20 Published 2002 Journal Heart Dis Section Title Doc Link 12147181 Disease Relevance 0.98 Pain Relevance 0.21
There were statistically significant increases in mortality with increasing levels of cardiac troponin I (P < 0.001).
Positive_regulation (increases) of cardiac troponin I
17) Confidence 0.20 Published 1996 Journal N. Engl. J. Med. Section Body Doc Link 8857017 Disease Relevance 0.14 Pain Relevance 0
The first positive result of cardiac troponin I was available within a mean time of 16.66 20.8 hours from admission.
Positive_regulation (result) of cardiac troponin I
18) Confidence 0.16 Published 2002 Journal Saudi Med J Section Body Doc Link 12070573 Disease Relevance 0 Pain Relevance 0
While the mean pre-stress serum values for both cardiac troponin T (0.117 +/- 0.12 microgram/L) and cardiac troponin I (0.235 +/- 0.89 microgram/L) were increased in the abnormal cardiac scan group, only the cTnT value proved to differ significantly from the normal group (p < 0.01).
Positive_regulation (increased) of cardiac troponin I associated with stress
19) Confidence 0.11 Published 2003 Journal Ren Fail Section Abstract Doc Link 12617333 Disease Relevance 0.92 Pain Relevance 0.08
Patients with elevated cardiac troponin I more often experienced Braunwald's class III (A and B) unstable angina associated with presence of marked ST-T changes on the electrocardiography than those from group II.
Positive_regulation (elevated) of cardiac troponin I associated with angina and arrhythmias 2 under development
20) Confidence 0.09 Published 1999 Journal Indian Heart J Section Abstract Doc Link 10327775 Disease Relevance 0.63 Pain Relevance 0.36

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox