INT169232

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.29
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
neurons 4
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 12 98.56 Very High Very High Very High
Pain 23 91.08 High High
dorsal root ganglion 53 90.56 High High
antagonist 13 88.48 High High
Migraine 1 83.88 Quite High
IPN 1 82.92 Quite High
Calcitonin gene-related peptide 16 70.64 Quite High
adenocard 15 70.60 Quite High
Neuropeptide 4 69.12 Quite High
Lasting pain 3 57.12 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 77 98.56 Very High Very High Very High
Bordatella Infection 4 97.04 Very High Very High Very High
Pain 26 91.08 High High
Headache 1 83.88 Quite High
Inflammatory Pain 1 82.92 Quite High
Neuropathic Pain 7 82.04 Quite High
Nociception 19 28.12 Quite Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar distribution of P2Y2 expression was observed in neurons of the rat TG [28].
Negative_regulation (distribution) of Gene_expression (expression) of P2Y2 in neurons associated with trigeminal ganglion
1) Confidence 0.31 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 1.64 Pain Relevance 0.71
Pharmacological blockade of P2Y receptors
Negative_regulation (blockade) of Gene_expression (receptors) of P2Y
2) Confidence 0.30 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.10 Pain Relevance 0.04
We also provide new original data showing a time-dependent downregulation of P2Y2 and P2Y4 receptor expression and function in purified SGCs cultures from TG, in comparison with primary mixed neuron-SGCs cultures.
Negative_regulation (downregulation) of Gene_expression (expression) of P2Y2 in neuron
3) Confidence 0.23 Published 2010 Journal Neuron Glia Biol. Section Abstract Doc Link 20604978 Disease Relevance 0.56 Pain Relevance 0.57

General Comments

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