INT169235

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.69
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (USF1) enzyme binding (USF1)
USF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 99.20 Very High Very High Very High
Inflammation 17 96.16 Very High Very High Very High
Catecholamine 12 93.84 High High
cytokine 2 92.72 High High
noradrenaline 14 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Combined Hyperlipidemia 127 100.00 Very High Very High Very High
INFLAMMATION 22 99.08 Very High Very High Very High
Disease 16 92.16 High High
Obesity 91 90.64 High High
Metabolic Syndrome 6 84.88 Quite High
Disorder Of Lipid Metabolism 19 78.52 Quite High
Dyslipidemia /

Combined Dyslipidemia

9 68.16 Quite High
Atherosclerosis 4 8.52 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Hyperlipidemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both of these modules are likely to be regulated by different genetic or environmental factors which contribute to the etiology of FCHL.


Negative_regulation (etiology) of FCHL associated with familial combined hyperlipidemia
1) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 1.08 Pain Relevance 0
In support of this notion, lipid synthesis stimulation by acylation-stimulating protein is decreased in FCHL [12], [13].
Negative_regulation (decreased) of FCHL
2) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.78 Pain Relevance 0.15
Nonsteroidal anti-inflammatory drugs prevent prostaglandin E(2) production by inhibiting the upstream enzymes cyclooxygenases 1 and 2.
Negative_regulation (inhibiting) of upstream enzymes cyclooxygenases 1 associated with inflammation and cinod
3) Confidence 0.01 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20605783 Disease Relevance 0.38 Pain Relevance 0.38
Nonsteroidal anti-inflammatory drugs prevent prostaglandin E2 production by inhibiting the upstream enzymes cyclooxygenases 1 and 2.
Negative_regulation (inhibiting) of upstream enzymes cyclooxygenases 1 associated with inflammation and cinod
4) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2937957 Disease Relevance 0.38 Pain Relevance 0.38

General Comments

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