INT169236

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 97.20 Very High Very High Very High
cytokine 3 94.64 High High
cINOD 18 89.96 High High
Inflammatory stimuli 2 43.20 Quite Low
Pain 8 5.64 Low Low
Arthritis 8 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 38 97.20 Very High Very High Very High
Atherosclerosis 4 32.28 Quite Low
Hypertension 2 31.52 Quite Low
Fever 6 6.04 Low Low
Pain 10 5.64 Low Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1.
Negative_regulation (inhibitor) of microsomal prostaglandin E synthase-1 Binding (binding) of
1) Confidence 0.36 Published 2010 Journal J. Biol. Chem. Section Title Doc Link 20605783 Disease Relevance 0.37 Pain Relevance 0.36
Exchange of the same residues 115–140 in human WT MPGES1 abrogated inhibitor binding.
Negative_regulation (inhibitor) of MPGES1 Binding (binding) of
2) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937957 Disease Relevance 0 Pain Relevance 0
We went on to locate individual residues that are important for inhibitor binding by exchanging single amino acid residues in rat MPGES1 toward the corresponding residue in the human enzyme and tested their ability to be inhibited by compound I.
Negative_regulation (inhibitor) of MPGES1 Binding (binding) of
3) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937957 Disease Relevance 0 Pain Relevance 0

General Comments

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